Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide.CRC mortalities are mainly caused by distant metastasis to the liver and the lungs.Although recent studies concerning chemokines and chemokine receptors (CKRs) have provided key clues at the molecular level, the mechanisms underlying the metastatic process are still poorly understood.Chemokines belong to a superfamily of small, cytokine-like proteins that induce cytoskeletal rearrangement and cellular directional migration through their interaction with G-protein-coupled receptors.Chemokines and CKRs are the essential and selective mediators of leukocyte migration in the inflammatory response, and they have recently been found to play a critical role in cancer cell metastasis.