Abstract: Primary testicular lymphoma comprises 1% to 9% of testicular neoplasms and represents 1% to 2% of all non-Hodgkin lymphomas.Histologically, the majority of the tumor consists of diffuse large B-cell non-Hodgkin lymphomas that are of intermediate-or high-grade neoplasm.Clinically, the disease typically presents as a painless testicular swelling that develops over a span of weeks to months.B symptoms such as fever, weight loss, and anorexia are present in 25% to 41% of the patients.This tumor is an aggressive type, with frequent invasion of the epididymis, spermatic cord, and scrotum, as well as a marked tendency to relapse, especially in the CNS.The treatment is mainly based on orchiectomy(mostly in stages ⅠE and ⅡE) regardless of its association with prophylactic irradiation of the scrotum and administration of intrathecal chemotherapy, cyclophosphamide, doxorubicin, vincristine, and prednisone regimen chemotherapy plus rituximab(R-CHOP)(stages ⅢE and ⅣE) and radiotherapy.The multi-modality treatment markedly improved progression-free and overall survival.We introduce as reference one case that received a multidisciplinary comprehensive discussion in the Department Lymphoma, Tianjin Medical University Cancer Hospital.