农晓琳, 徐铭竹, 李昊, 杨亦萍, 农东晓, 曹阳, 李佳荃, 胥航, 黎燕宁. CXCR4 CD44 CD133表达在舌鳞状细胞癌患者生存分析中的价值[J]. 中国肿瘤临床, 2013, 40(14): 832-837. DOI: 10.3969/j.issn.1000-8179.2013.14.005
引用本文: 农晓琳, 徐铭竹, 李昊, 杨亦萍, 农东晓, 曹阳, 李佳荃, 胥航, 黎燕宁. CXCR4 CD44 CD133表达在舌鳞状细胞癌患者生存分析中的价值[J]. 中国肿瘤临床, 2013, 40(14): 832-837. DOI: 10.3969/j.issn.1000-8179.2013.14.005
shu
Xiaolin NONG, Mingzhu XU, Hao LI, Yiping YANG, Dongxiao NONG, Yang CAO, Jiaquan LI, Hang XU, Yanning LI. Survival analysis of tongue squamous cell carcinoma with CXCR4, CD44 and CD133 expression[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(14): 832-837. DOI: 10.3969/j.issn.1000-8179.2013.14.005
Citation: Xiaolin NONG, Mingzhu XU, Hao LI, Yiping YANG, Dongxiao NONG, Yang CAO, Jiaquan LI, Hang XU, Yanning LI. Survival analysis of tongue squamous cell carcinoma with CXCR4, CD44 and CD133 expression[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(14): 832-837. DOI: 10.3969/j.issn.1000-8179.2013.14.005
shu

CXCR4 CD44 CD133表达在舌鳞状细胞癌患者生存分析中的价值

Survival analysis of tongue squamous cell carcinoma with CXCR4, CD44 and CD133 expression

    摘要
  • 摘要:
      目的  探讨影响舌鳞状细胞癌患者术后生存的相关因素。
      方法  回顾性分析经病理确诊并行手术治疗的44例舌鳞癌患者临床资料，采用免疫组织化学方法检测不同病理分级舌鳞癌患者癌组织中CXCR4、CD44、CD133的表达情况。将可能影响患者术后生存的指标进行Kaplan-Meier检验后，采用Cox比例风险回归模型进行多因素分析。
      结果  本研究44例舌鳞癌标本中，高分化29例，中、低分化15例；Ⅰ期11例，Ⅱ期12例，Ⅲ期8例，Ⅳ期13例。各病理分级病例CXCR4、CD44、CD133阳阳性率分别是79.54%（35/44）、77.27%（34/44）和75.00%（33/44）。CXCR4、CD44、CD133在舌鳞癌各病理分级组在之间表达强度差异均有统计学意义（P < 0.05），且CXCR4、CD44、CD133分别与转移、复发也成正相关。Cox模型多因素分析提示：CXCR4表达情况、临床分期、颈部转移为本组舌鳞癌患者预后独立的影响因素及死亡的危险因素。
      结论  CXCR4、CD44、CD133的表达与舌鳞癌的恶性程度存在相关性，CXCR4表达情况、临床分期、颈部转移为术后评价舌鳞癌患者生存的重要指标。

     

    Abstract:
      Objective  This study aimed to analyze the correlation of the expression of CXCR4, CD44, and CD133 proteins with the clinicopathological characteristics of patients to identify the factors affecting the post-operation survival rate of tongue squamous cell carcinomas (TSCCs).
      Methods  Clinical data of 44 patients with TSCCs were collected and retrospectively analyzed. The diagnoses of all cases were pathologically confirmed. CXCR4, CD44, and CD133 expression in 44 TSCCs patients with different pathologicalgrades was examined immunohistochemically. Survival curves were processed in accordance with the Kaplan-Meier method. The Coxregression model was used for the multivariate analysis of relevant clinical and survival data
      Results  Among the 44 examined TSCCspatients, 29 cases were well differentiated and 15 were moderately or poor differentiated; 11 cases were stage Ⅰ, 12 were stage Ⅱ, 8were stage Ⅲ, and 13 were stage Ⅳ. Positive staining of CXCR4, CD44, and CD133 was found in all cases with different degrees. According to the pathological tumor grade, the positive rates of CXCR4, CD44, and CD133 expression were 79.54% (35/44 cases)77.27% (34/44 cases), and 75.00% (33/44 cases), respectively. Expression of CXCR4, CD44, and CD133 significantly differed betweendifferent histological grades (P<0.05). Correlation analysis indicated that the expression of CXCR4, CD44, and CD133 was positivelycorrelated with the metastasis, recurrence of TSCCs. COX multivariate analysis indicated that CXCR4 expression, clinical stage, andneck metastasis were independent prognostic predictors of TSCCs patients and risk factors of death.
      Conclusion  CXCR4, CD44, andCD133 may be correlated with the malignancy of TSCCs. CXCR4 expression, clinical stage, cervical lymph node metastasis were the correlated prognosis factors of TSCC patients after operation.

     

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