Abstract:
Objective This study aimed to analyze and summarize the clinicopathologic characteristics and treatment protocols of large cell lung carcinoma (LCLC).
Methods Clinicopathologic data of 83 cases with LCLC confirmed by pathology in 2012 were retrospectively reviewed.
Results Exactly 83 cases of LCLC accounted for 5.4% of lung cancer in 2012.Sixty-three cases were male and twenty were female.The average age was 60.4 years old.The average maximum diameter of the tumor was 4.6 cm.The common manifestations in imageology were peripheral type.Only four cases were correctly diagnosed by sputum exfoliocytology, biopsy of bronchofibroscope, and paracentesis before surgery.Sixty-three cases (76%) underwent surgical resection, and pulmonary lobectomy was mainly selected.Postoperative pathology diagnosis indicated that 39 cases were classic large cell carcinoma, 31 were large cell neuroendocrine carcinoma, 2 were combined large cell neuroendocrine carcinoma, 8 were basaloid carcinoma, 2 were clear cell carcinoma, and 1 was lymphoepithelioma-like carcinoma.Each subtype of LCLC had respective characteristics of pathomorphology and immunohistochemistry.Lymph node metastasis occurred in 62 cases (75%).
Conclusion The incidence rate of LCLC, which is a highly aggressive malignancy, is low.The clinical manifestation and imageology characteristics of LCLC do not have specificity, and its final diagnosis depends on pathology diagnosis.Operation is the main treatment method.Improving the diagnosis rate of LCLC and further subdividing the pathological subtypes are important for a normalized comprehensive treatment of LCLC.