路三军, 杨学丽, 桂洪武, 姜琳娜, 孙丽娟. 近端胃腺癌中DKK-1和β-catenin的表达及其相关性[J]. 中国肿瘤临床, 2013, 40(17): 1038-1041. DOI: 10.3969/j.issn.1000-8179.20130014
引用本文: 路三军, 杨学丽, 桂洪武, 姜琳娜, 孙丽娟. 近端胃腺癌中DKK-1和β-catenin的表达及其相关性[J]. 中国肿瘤临床, 2013, 40(17): 1038-1041. DOI: 10.3969/j.issn.1000-8179.20130014
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Sanjun LU, Xueli YANG, Hongwu GUI, Linna JIANG, Lijuan SUN. Expression and relativity of DKK-1 and β-catenin in proximal gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(17): 1038-1041. DOI: 10.3969/j.issn.1000-8179.20130014
Citation: Sanjun LU, Xueli YANG, Hongwu GUI, Linna JIANG, Lijuan SUN. Expression and relativity of DKK-1 and β-catenin in proximal gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(17): 1038-1041. DOI: 10.3969/j.issn.1000-8179.20130014
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近端胃腺癌中DKK-1和β-catenin的表达及其相关性

Expression and relativity of DKK-1 and β-catenin in proximal gastric cancer

    摘要
  • 摘要:
      目的   探讨DKK-1和β-catenin蛋白表达在胃近端癌发生过程中的作用。
      方法   采用免疫组织化学S-P方法分别检测61例胃近端癌、癌旁组织及20例正常胃黏膜组织的DKK-1和β-catenin蛋白表达，并分析其临床意义。
      结果   胃近端癌中DKK-1阳性表达率和β-catenin异常表达率分别为34.4%（21/61）和68.9%（42/61），癌旁组织中DKK-1阳性表达率和β-catenin异常表达率分别为8.2%（5/61）和6.6%（4/61），正常组织中DKK-1阳性表达率和β-catenin异常表达率分别为15.0%（3/20）和10.0%（2/20）。胃近端癌的表达明显高于其他两者（P < 0.05），胃近端癌中DKK-1和β-catenin的表达呈正相关（r=0.454，P < 0.05），而在癌旁组织及正常胃黏膜中的表达无明确相关性。
      结论  DKK-1高表达和β-catenin异常表达上升与胃近端癌的发生密切相关。

     

    Abstract:
      Objective  To explore the role of DKK-1 and β-catenin expressions in progression of proximal gastric cancer (PGC).
      Methods  The expression of DKK-1 and β-catenin in 61 cases with PGC and para-neoplastic tissues and 20 cases with normal gastric mucosa was detected by immunohistochemistry. The related clinical significance in the cases was studied.
      Results  The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in the tissue sections of PGC were 34.4% (21/61) and 68.9% (42/61), respectively. The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in para-carcinoma tissues were 8.2% (5/61) and 6.6%(4/61), respectively. The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in normal gastric mucosa were 15.0% (3/20) and 10.0% (2/20), respectively. The expression rate was significantly higher in PGC than that in the other tissues (P < 0.05). The expression of DKK-1 was positively related to that of β-catenin in PGC (r=0.454, P < 0.05), but not in the others.
      Conclusion  Higher expressions of DKK-1 and the abnormal expression of β-catenin are closely related to the occurrence of PGC.

     

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