江西省靖安县农村妇女高危型人乳头状瘤病毒感染的横断面研究

徐小玲; 李隆玉; 余葆华; 罗筱霞; 李凌

doi:10.3969/j.issn.1000-8179.20130558

江西省靖安县农村妇女高危型人乳头状瘤病毒感染的横断面研究

doi: 10.3969/j.issn.1000-8179.20130558

徐小玲^①,
李隆玉^②,
余葆华^①,
罗筱霞^①,
李凌^②, ,

①.
江西省靖安县子宫颈癌防治研究所（江西省靖安县330600）
②.
江西省妇幼保健院

基金项目:

江西省卫生厅重大科研项目 20114036

详细信息

通讯作者:
李凌 lilingjxnc@yahoo.com.cn

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出版历程
- 收稿日期: 2013-04-08
- 修回日期: 2013-05-25

High-risk human papillomavirus infection among rural women of Jing'an County in Jiangxi Province: a cross-sectional study

Xiaoling XU^①,
Longyu LI^②,
Baohua YU^①,
Xiaoxia LUO^①,
Ling LI^{②
, ,}

①.
Jing'an Institute of Cervical Cancer Prevention and Treatment, Yichun 330600, China
②.
Department of Oncology, Jiangxi Maternal and Child Health Institute, Nanchang 330006, China

Funds:

the Major Scientific Projects of Health Department of Jiangxi Province 20114036

More Information

Corresponding author: Ling LI; E-mail: lilingjxnc@yahoo.com.cn

摘要

摘要: 目的调查江西省靖安县农村女性子宫颈上皮内高危型人乳头状瘤病毒（high-risk human papillomavirus，hr-HPV）的感染状况。方法 2012年5月至2012年11月在江西省靖安县地区对35~59岁女性进行人群横断面调查，纳入研究的4 673例受检者中2 491例采用了杂交捕获法（HC-2）方法检测hr-HPV，另外2 182例采用凯普医用核酸分子快速导流杂交基因芯片技术进行hr-HPV检测并分型。结果 hr-HPV感染率为11.9%，混合感染占41.5%。在进行了分型的2 182例中HPV52型感染率最高（2.8%），其次分别是58、16和39型。hr-HPV感染率在靖安县山区和平原地区之间无差异，年龄分布则有显著性差异（P < 0.001）。结论江西省靖安县农村女性hr-HPV感染率与我国其他地区近似，HPV52和58型是该地区优势感染型，hr-HPV感染防治策略应针对不同地域人群的特点有所不同。
- 高危型人乳头状瘤病毒 /
- 亚型 /
- 子宫颈上皮内瘤样病变 /
- 流行病学
Abstract: Objective To investigate the prevalence of cervical infection with high-risk human papillomavirus (hr-HPV) among the rural women of Jing-an County in Jiangxi Province. Methods A population-based cross-sectional study was conducted among rural women of ages 35 years to 59 years in Jing-an County between May 2012 and November 2012. A total of 4 673 women were enrolled. Hybrid capture2 (hc2) was detected in 2 491 women, whereas HybriMax was detected in 2 182 women to understand the different hr-HPV types. Results The overall hr-HPV prevalence was 11.9%. Multiple-type infections accounted for 41.5%. The most commonly seen hr-HPV type was HPV52 (2.8%), followed by HPV58, HPV16, and HPV39. No significant difference was observed in the prevalence of hr-HPV infection between women in the mountainous and the plain areas in Jing-an County. However, the age distribution of HPV infection significantly differed (P < 0.001). Conclusion Hr-HPV infection rate in Jing-an County was close to that of other areas in China. HPV52 and HPV58 appeared to be the most prevalent HPV types and should be employed as a basis for HPV prevention in this area.
- high-risk human papillomavirus /
- genotype /
- cervical neoplasia /
- epidemiology

HTML全文

图 1 靖安hr-HPV亚型的地区分布情况

Figure 1. Endemic distribution of hr-HPV subtypes in Jing'an county

下载: 全尺寸图片幻灯片

表 1 江西省靖安县2 182名农村妇女人群hr-HPV感染率及型别分布

Table 1. Prevalence of various hr-HPV types among 2 182 rural women in Jing'an county

表 2 hr-HPV感染率及其95%可信区间的年龄别分布

Table 2. Age-specific prevalence of hr-HPV and corresponding 95% CI

表 3 hr-HPV感染在正常人群及病理诊断异常人群中的分布

Table 3. Prevalence of hr-HPV in populations with normal and abnormal pathologic diagnosis

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