Abstract:
Hypoxia is a common characteristic in solid tumors.With the regulation of the transcription of multiple target genes, HIF-1α plays an important role in the energy metabolism, proliferation, and apoptosis of tumor cells.HIF-1α contributes to the adaptation of tumor cells and tissue to hypoxia stress through these processes.It also promotes tumor angiogenesis and increases their invasive ability and the resistance to radio and chemotherapy.Cancer treatment targeting on HIF-1α is an important potential therapy.