CDX2 COX-2和NF-κB在胃癌和癌前病变中的表达和意义

苏帅; 陈鑫; 姜葵; 曹晓仓; 王邦茂

doi:10.3969/j.issn.1000-8179.20130582

CDX2 COX-2和NF-κB在胃癌和癌前病变中的表达和意义

Expression of CDX2, COX-2, and NF-κB in gastric carcinoma and precancerous lesions

摘要

摘要:
目的探讨CDX2、COX-2和NF-κB在胃癌和癌前病变中的表达以及相互之间的关系。
方法采用免疫组织化学染色法（SP法和SABC法）检测正常胃黏膜组20例、胃癌癌前病变组38例及胃癌组48例中CDX2、COX-2和NF-κB的表达情况。
结果 NF-κB和COX-2在胃癌组中的表达明显增强，其阳性率显著高于正常胃黏膜组（P < 0.01）和癌前病变组（P < 0.01）；CDX2在正常胃黏膜组中低表达，癌前病变组CDX2的表达阳性率高于胃癌组（P < 0.01）；CDX2与胃癌分化程度、胃癌的病灶大小和浸润深度相关（P < 0.05）；COX-2和NF-κB与胃癌病灶大小、浸润深度和淋巴结转移相关（P < 0.05）；NF-κB与COX-2在胃癌组织中表达呈正相关；CDX2与COX-2、NF-κB的表达呈负相关。
结论 CDX2、COX-2和NF-κB可能相互作用参与了胃癌的发生发展和侵袭转移。

Abstract:
Objective To detect the expression of CDX2, COX-2, and NF-κ B in the tissues of gastric carcinoma (GC), precancerous lesions, and normal gastric mucosa and to in vestigate the correlation among CDX2, COX-2, and NF-κB.
Methods Data on the expression of CDX2, COX-2, and NF-κ B were evaluated using immunohistochemistry in 60 cases with GC, 45 cases with precancerous lesions, and 20 cases with normal tissues. The protein levels in different pathological tissues, as well as their correlation with GC, were analyzed.
Results The positive rates of NF-κB and COX-2 proteins were significantly higher in GC group than those in precancerous lesion and normal tissue groups (P < 0.05). CDX2 was expressed in GC and precancerous lesion groups but poorly expressed in the normal mucosa. The positive rate of CDX2 expression was significantly higher in precancerous lesion group than that in GC group (P < 0.01). NF-κ B expression was positively correlated with COX-2 in GC (P < 0.01), whereas CDX2 expression was negatively correlated with COX-2 and NF-κB in GC (P < 0.01).
Conclusion CDX2, COX-2, and NF-κB are possibly correlated with one another, and they cooperate during the onset, progression, and metastasis of GC.

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