刘冬, 叶敏娟, 杨越波. HPV基因型与宫颈病变的关系探讨[J]. 中国肿瘤临床, 2013, 40(24): 1531-1534. DOI: 10.3969/j.issn.1000-8179.20130648
引用本文: 刘冬, 叶敏娟, 杨越波. HPV基因型与宫颈病变的关系探讨[J]. 中国肿瘤临床, 2013, 40(24): 1531-1534. DOI: 10.3969/j.issn.1000-8179.20130648
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Dong LIU, Minjuan YE, Yuebo YANG. Relationship between human papillomavirus gene types and cervicervical[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(24): 1531-1534. DOI: 10.3969/j.issn.1000-8179.20130648
Citation: Dong LIU, Minjuan YE, Yuebo YANG. Relationship between human papillomavirus gene types and cervicervical[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(24): 1531-1534. DOI: 10.3969/j.issn.1000-8179.20130648
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HPV基因型与宫颈病变的关系探讨

Relationship between human papillomavirus gene types and cervicervical

    摘要
  • 摘要:
      目的  了解HPV基因型与宫颈病变的关系。
      方法  选取2010年3月至2011年1月在广州中山大学第三医院妇科就诊并愿意接受HPV检查和问卷调查的妇女为对象。剔除标准：1）已切除子宫；2）已行宫颈锥切；3）不愿意参加本研究。入选360例，年龄为19~66岁，平均为35.6岁，户籍均为广州地区。利用核酸分子杂交技术检测21种HPVDNA。宫颈正常/炎症组为256例，CIN1组为34例，CIN2/3组为61例，宫颈癌组为9例。
      结果  HPV感染率宫颈正常/炎症组为18.4%（47/256），CIN1组为67.6%（23/34），CIN2/3组为96.7%（59/61），宫颈癌组为100%（9/9）。CIN1组、CIN2/3组HPV感染率均比正常/炎症组高（P < 0.001）；CIN2/ 3组的HPV感染率比CIN1组高（P < 0.001）。CIN主要感染类型依次为HPV16（44.2%）、HPV58（24.2%）、HPV52（11.6%）、HPV33（8.4%）。宫颈癌主要感染类型为HPV16（88.9%）。
      结论  随着宫颈病变程度进展HPV感染率呈升高的趋势，HPV16、58、52、33相关的感染与宫颈癌前病变关系密切，应引起足够重视，其中HPV16感染易致病变进展及癌变发生。

     

    Abstract:
      Objective  To investigate the relationship between human papilloma virus (HPV) gene types and cervical diseases.
      Methods  The subjects included women with HPV who were diagnosed in the Outpatient Department of the Third Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) from March 1, 2010 to January 31, 2011. A total of 21 HPV DNA types were found in the women using DNA flow-though hybridization genotyping technique, and a questionnaire-type survey was conducted on these patients. In this study, 256 cases of normal or inflamed cervix, 34 cases of cervical intraepithelial neoplasia I (CIN Ⅰ), 61 cases of CIN Ⅱ or CIN Ⅲ, and 9 cases of cervical cancer were analyzed.
      Results  The HPV infection rates were 18.4% in the normal cervical or inflammation group, 67.6% in the CIN Ⅰ group, 96.7% in the CIN Ⅱ or CIN Ⅲ group, and 100% in the cervical cancer group. The HPV infection rate was higher in the CIN I group than in the normal HPV infection or inflammation group (P < 0.001) and was higher in the CIN Ⅱ or CIN Ⅲ groups than in the CIN I group (P < 0.001). The main types of infection were HPV16 (44.2%), HPV58 (24.2%), HPV52 (11.6%), and HPV33 (8.4%) in the CIN groups. The main type of infection was HPV16 in the cervical cancer group (88.9%).
      Conclusion  Cases of cervical lesions are increasing. With this prevalence of HPV, considerable attention should be focused on HPV16-, 58-, 52-, and 33-related infections and cervical lesions. Among them, HPV16 infection is the primary cause of disease progression and carcinogenesis.

     

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