Abstract:
Objective To investigate the clinical value of serological test indicators in the identification of primary and metastaticliver cancers.
Methods We detected the serum levels of ALT, AST, ALP, TBIL, DBIL, GGT, CHE, 5'-NT, CA199, CEA, and AFP inprimary hepatic carcinoma (PHC; 120 cases), metastatic hepatic carcinoma (MHC; 135 cases), and no liver metastatic control (135 cases)groups. The methods used were variance analysis and Scheffe test. ROC curve analysis was used to determine the diagnostic valueof CA199, CEA, and AFP in PHC and MHC.
Results The difference between the serum levels of AST, ALP, GGT, 5'-NT, AFP, anCEA of the PHC and MHC groups was statistically significant (P < 0.05). The AFP, CEA, and CA199 areas under the ROC curve of thePHC and MHC groups revealed that AFP diagnosis of primary liver cancer had certain accuracy, whereas CEA and CA199 have somediagnostic value in differentiating primary and metastatic liver cancers.
Conclusion The detection of serum levels of AST, GGT, 5'-NT, AFP, CA199, and CEA in malignant tumor was a preliminary diagnosis of liver metastasis and can provide evidence for the differentialdiagnosis of PHC and MHC.