-
摘要:
目的 观察胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液的临床疗效。 方法 将90例恶性胸腔积液患者随机分为治疗组31例,对照组A 29例,对照组B 30例。治疗组予以胸腔注入铜绿假单胞菌注射液治疗,对照组A和B分别予以胸腔注入顺铂和白介素-2治疗。比较3组临床疗效及不良反应。 结果 治疗组总有效率80.6%,对照组A和对照组B的总有效率分别为51.7%和56.7%,治疗组有效率高于对照组,差异具有统计学意义(P<0.05),同时,治疗组严重不良反应发生率低。 结论 胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液疗效明显,不良反应轻,值得临床推广应用。 Abstract:Objective To observe the effect of thoracic infusion of pseudomonas aeruginosa injection in malignant pleural effusion. Methods A total of 90 patients with malignant pleural effusion were randomly divided into treatment group (31 cases), control group A (29 cases) and control group B(30 cases). Treatment group was treated with pseudomonas aeruginosa through intrathoracic infusion. Control group A and B were respectively treated with cisplatin and interleukin-2 through intrathoracic infusion. The clinical efficacy and adverse reaction were compared among the three groups. Results The total effective rate of treatment group was 80.6%, the total effective rates of the control groupAand B were 51.7% and 56.7% respectively.Compared with that of contral groups, the total effective rate of treatment group was higher, and the differences were statistically significant (P<0.05). The incidence of serious side effects and toxicity was lower in treatment group than in control groups. Conclusion The effect of thoracic infusion of pseudomonas aeruginosa injection for malignant pleural effusion is significant, and the adverse reaction is mild. Thus it is worth to be promoted clinically. -
Key words:
- pseudomonas aeruginosa injection /
- malignant pleural effusion /
- cisplatin /
- interleukin-2
-
表 1 临床疗效比较例 (%)
Table 1. Comparison of clinical effects [case(%)]
表 2 不良反应比较例 (%)
Table 2. Comparision of side effects [case(%)]
-
[1] Dalokay K, Hadi A, Sevket K, et al. Management of recurrent malignant pleueal effusion with chemical pleurodesis[J]. Surg Today, 2005, 35(8): 634-638. doi: 10.1007/s00595-005-2996-5 [2] Khaleeq G, Musani AI. Emerging paradigms in the management of malignant pleural effusions[J]. Respir Med, 2008, 102(7): 939-948. doi: 10.1016/j.rmed.2008.01.022 [3] Uzbeck MH, Almeida FA, Sarkiss MG, et al. Management of Malignant Pleural Effusions[J]. Adv Ther, 2010, 27(6): 334-347. doi: 10.1007/S12325-010-0031-8 [4] 王爱秋. 香菇多糖联合顺铂腹腔灌注治疗肿瘤患者腹腔积液的临床疗效[J]. 中国医药指南, 2013, 11(6): 596-597. doi: 10.3969/j.issn.1671-8194.2013.06.475 [5] 曹丹, 侯梅, 勾红峰, 等. 热疗联合胸腔内注射药物治疗恶性胸腔积液的疗效观察[J]. 中国肺癌杂志, 2006, 9(3): 286-288. doi: 10.3779/j.issn.1009-3419.2006.03.18 [6] 马少林, 李润浦, 王艳丽, 等. 博莱霉素联合白介素-2及凝血酶治疗恶性胸腔积液的临床观察[J]. 现代肿瘤医学, 2013, 21(3): 557-559. doi: 10.3969/j.issn.1672-4992.2013.03.34 [7] 王浦华, 沈通一, 葛海燕. 铜绿假单胞菌制剂在恶性肿瘤中的辅助治疗作用. 世界华人消化杂志, 2010, 18(30): 3171-3174. [8] Liu ZB, Hou YF, Dong M, et al. PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of capases in the human breast cancer cell lines[J]. J Cell Biochem. 2009, 108(1): 195-206. doi: 10.1002/jcb.22241 [9] 张帅, 姜伟, 曹志伟, 等. 铜绿假单胞注射液联合PC方案治疗晚期肺腺癌的疗效评价[J]. 中国肿瘤临床, 2012, 39(16): 1208-1210. doi: 10.3969/j.issn.1000-8179.2012.16.019 [10] 万莉, 何耿劲. 铜绿假单胞注射液治疗恶性胸腔积液的临床观察[J]. 临床肺科杂志, 2013, 18(3): 401-402. doi: 10.3969/j.issn.1009-6663.2013.03.006 [11] 太祥, 许虎, 雷常成, 等. 胸腔灌注铜绿假单胞菌制剂治疗恶性胸腔积液的疗效观察[J]. 临床合理用药, 2013, 6(1): 26-27. doi: 10.3969/j.issn.1674-3296.2013.01.019 [12] 徐虹, 杨雨田, 卢慧宇. 铜绿假单胞菌制剂治疗肺癌伴恶性胸水40例[J]. 军医进修学院学报, 2009, 30(6): 841-843. https://www.cnki.com.cn/Article/CJFDTOTAL-JYJX200906035.htm [13] 朱亚军, 李森. 绿脓杆菌制剂治疗恶性胸腔积液的临床观察[J]. 临床实用癌症杂志, 2008, 23(1): 84. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZL201609019.htm
计量
- 文章访问数: 65
- HTML全文浏览量: 10
- PDF下载量: 2
- 被引次数: 0