李韶今, 张相民, 李荣, 刘联斌, 叶永强, 王冬梅, 罗忠兵. 非小细胞肺癌组织中P-ACC及COX-2的相关性研究[J]. 中国肿瘤临床, 2014, 41(1): 68-72. DOI: 10.3969/j.issn.1000-8179.20131266
引用本文: 李韶今, 张相民, 李荣, 刘联斌, 叶永强, 王冬梅, 罗忠兵. 非小细胞肺癌组织中P-ACC及COX-2的相关性研究[J]. 中国肿瘤临床, 2014, 41(1): 68-72. DOI: 10.3969/j.issn.1000-8179.20131266
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LI Shaojin, ZHANG Xiangmin, LI Rong, LIU Lianbin, YE Yongqiang, WANG Dongmei, LUO Zhongbing. Correlation of P-ACC and COX-2 expression in non-small cell lung cancer tissues[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(1): 68-72. DOI: 10.3969/j.issn.1000-8179.20131266
Citation: LI Shaojin, ZHANG Xiangmin, LI Rong, LIU Lianbin, YE Yongqiang, WANG Dongmei, LUO Zhongbing. Correlation of P-ACC and COX-2 expression in non-small cell lung cancer tissues[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(1): 68-72. DOI: 10.3969/j.issn.1000-8179.20131266
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非小细胞肺癌组织中P-ACC及COX-2的相关性研究

Correlation of P-ACC and COX-2 expression in non-small cell lung cancer tissues

    摘要
  • 摘要:
      目的   探讨非小细胞肺癌组织中乙酰辅酶A羧化酶磷酸化后的产物（P-ACC）与环氧合酶-2（COX-2）的表达及其与肿瘤大小、淋巴结转移、临床分期及病理类型的关系，并研究两者的相关性。
      方法   以62例非小细胞肺癌患者的肺癌组织作为研究组，20例因其他它原因行肺叶切除患者的正常肺组织作为对照组。应用免疫组织化学SP法检测肺癌组织及正常肺组织中P-ACC、COX-2的表达情况。
      结果   P-ACC、COX-2在非小细胞肺癌和正常肺组织中的阳性表达差异有统计学意义（P < 0.05）。在非小细胞肺癌中，P-ACC的阳性表达与肿瘤大小显著相关（P < 0.05），而与淋巴结转移、临床分期及病理类型无关；COX-2的阳性表达与肿瘤大小、淋巴结转移、临床分期及病理类型无关。P-ACC与COX-2的阳性表达之间呈显著负相关（r=-2.37，P=0.032）。
      结论   P-ACC在非小细胞肺癌组织中的阳性表达降低；COX-2在非小细胞肺癌组织中阳性高表达，二者呈显著负相关，提示P-ACC阳性表达降低可能激活COX-2阳性表达，可促进非小细胞肺癌的发生、发展及侵袭转移。

     

    Abstract:
      Objective   A study was conducted to determine the expression of acetyl-coa carboxylase product of phosphorylation (P-ACC) and an enzyme called cyclooxygenase 2 (COX-2) in non-small cell lung cancer (NSCLC) tissue, as well as the relationship and correlations between tumor size, lymph node metastasis, clinical stage, and pathological type.
      Methods   Sixty-two patients with NSCLC lung cancer tissues were included in the patient group, whereas 20 patients who underwent lobectomy for other reasons and had normal lung tissues were included in the control group. Immunohistochemical streptavidin peroxidase method was used to detect the expression of P-ACC and COX-2 in lung cancer and normal lung tissues.
      Results   The positive expressions of P-ACC and COX-2 in NSCLC lung cancer and normal lung tissues were significantly different (P < 0.05). In NSCLC tissues, the positive expression of P-ACC was significantly associated with tumor size (P < 0.05), but was not significantly associated with lymph node metastasis, clinical stage, and pathological type. We found no correlation between the positive expression of COX-2 and tumor size, lymph node metastasis, clinical stage and pathological type. Further analysis revealed that the positive expression of P-ACC and COX-2 in NSCLC was significantly and negatively correlated (r=-2.37, P=0.032).
      Conclusion   The positive expression of COX-2 in NSCLC greatly increased compared with that of P-ACC, and a significantly negative correlation was observed between them. We propose that the positive expression of P-ACC reduction may activate the positive expression of COX-2 and promote the occurrence, development, invasion, and metastasis of NSCLC.

     

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