肺癌患者外周血淋巴细胞亚群与预后的关系

魏熙胤; 张翠翠; 臧凤琳; 李凯

doi:10.3969/j.issn.1000-8179.20131278

肺癌患者外周血淋巴细胞亚群与预后的关系

doi: 10.3969/j.issn.1000-8179.20131278

天津医科大学肿瘤医院肿瘤研究所公共实验室，国家肿瘤临床医学研究中心，天津市肿瘤防治重点实验室（天津市300060）

基金项目:

天津市科委抗癌重大专项攻关计划 12ZCDZSY15600

详细信息

作者简介:
魏熙胤研究方向为流式细胞术应用。E-mail：weixiyin@126.com

通讯作者:
Kai LI; likai5@medmail.com.cn

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- 文章访问数: 11
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- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2013-08-08
- 修回日期: 2013-11-08
- 刊出日期: 2014-03-30

The correlation of peripheral blood lymphocyte subsets with prognosis in lung cancer patients

Department of Public Laboratory, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

Funds:

Tianjin Anticancer Special Funds for Major Scientific Projects 12ZCDZSY15600

摘要

摘要: 目的探讨肺癌患者外周血T细胞亚群及NK细胞与临床病理特征及预后的关系。方法回顾性观察102例肺癌患者、12例肺良性疾病患者及23例健康体检者，记录其外周血T细胞亚群及NK细胞占外周血淋巴细胞的百分比，对比二者分布在肺癌、肺良性疾病及健康体检者之间的差异，并对患者的临床病理资料进行回顾性分析，分析淋巴细胞亚群与预后的关系及其与临床病理特征的相关性。结果肺癌患者外周血CD4⁺T细胞低于健康体检者，而CD8⁺T细胞却较高，差异有统计学意义（P < 0.05）；单因素分析显示T细胞亚群及NK细胞分布与预后并无显著关系（P>0.05），而与淋巴结转移、TNM分期、肿瘤标志物等存在相关性（P < 0.05）。结论肺癌患者外周血T亚群及NK细胞分布异常，动态监测患者外周血T细胞亚群及NK细胞有助于评估患者免疫功能，有望成为判断患者预后的一种指标。
- 肺癌 /
- 细胞免疫 /
- 淋巴细胞亚群 /
- 预后
Abstract: Objective To study the relationship of lymphocyte subsets with prognosis and clinico-pathologic features in lung cancer patients. Methods Flow cytometry was used to analyze the distribution of T-lymphocyte subsets and natural killer cells in the peripheral blood of lung cancer patients, patients with benign pulmonary diseases, and healthy controls. The peripheral-blood lymphocyte levels of the subjects were compared. Clinical data obtained from 102 lung cancer cases were reviewed retrospectively, and the relationship of lymphocyte subsets with prognosis and clinico-pathologic features was analyzed. Results The level of CD4⁺T cells was lower in the peripheral blood of lung cancer patients than that of the healthy controls (P < 0.05); however, the level of CD8⁺T cells was higher in lung cancer patients than in the healthy controls (P < 0.05). Univariate analysis revealed that T-lymphocyte subsets and natural killer cells were not influential factors in the overall survival of lung cancer patients (P>0.05). However, the abnormal distribution of lymphocyte subsets was related to lymphatic metastasis, TNM stage, and tumorigenesis P < 0.05). Conclusion The distribution of T-lymphocyte subsets and natural killer cells was abnormal in the peripheral blood of lung cancer patients, and the dynamic changes in distribution can help assess the immune functions of lung cancer patients. Cellular immune function can act as a prognostic indicator in lung cancer patients.
- lung cancer /
- cellular immune function /
- lymphocyte subsets /
- prognosis

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表 1 肺癌患者、良性疾病及健康对照者各淋巴细胞分布  %，x±s

Table 1. Lymphocyte distributions in lung cancer patients, patients with benign pulmonary disease, and healthy controls   %, x±s

表 2 免疫细胞分布与临床病理特征的关系  %，x±s

Table 2. The relationship of distribution of the immunology and clinicopathologic characteristics   %, x±s

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