乳腺癌中FoxP3表达与上皮间质转化的相关性及其意义

霍莉莉; 李慧; 魏枫; 赵华; 任秀宝

doi:10.3969/j.issn.1000-8179.20131533

乳腺癌中FoxP3表达与上皮间质转化的相关性及其意义

Clinical significance of FoxP3 and the correlation of FoxP3 expression with epithelial-mesenchymal transition in breast cancer

摘要

摘要:
目的探讨乳腺癌组织FoxP3、TGF-β1的表达和上皮间质转化(EMT)的相互关系及其临床意义。
方法免疫组织化学法检测74例乳腺癌组织中FoxP3、TGF-β1、E-Cadherin、N-Cadherin、Vimentin和Fibronectin的表达情况, 分析乳腺癌FoxP3蛋白表达与临床病理特征的关系, 以及FoxP3、TGF-β1的表达和EMT发生之间的关系。
结果 FoxP3与TGF-β1的表达率和EMT的发生率分别为36.5%(27/74)、39.2%(29/74)和40.5%(30/74)。乳腺癌FoxP3表达与淋巴结转移相关(P < 0.05), 与其他临床病理特征无关(P>0.05)。FoxP3和TGF-β1的表达之间存在相关性, 而TGF-β1可以促进EMT发生(P < 0.05)。
结论 FoxP3的表达与乳腺癌淋巴结转移和EMT的发生相关, 可能作为预测乳腺癌转移可能性的标记物。

Abstract:
Objective This study aims to investigate the correlation between the expression of FoxP3, TGF-β1, and epithelial-mesenchymal transition (EMT) in breast cancer and to determine the clinical significance of FoxP3.
Methods The expression of FoxP3, TGF-β1, E-Cadherin, N-Cadherin, Vimentin, and Fibronectin protein were detected in the cancer cells of 74 cases with breast carcinoma via immunohistochemistry.The correlation of FoxP3 protein with clinico-pathologic features of breast carcinoma and the relationships among the expressions of FoxP3, TGF-β1, and epithelial-mesenchymal transition (EMT) were analyzed.
Results The expression rates of FoxP3, TGF-β1, and EMT are 36.5%(27/74), 39.2%(29/74), and 40.5%(30/74), respectively.The FoxP3 protein expression in breast cancer is correlated with lymph node metastasis (P < 0.05) but not with other clinico-pathological features (P>0.05). The expression of FoxP3 is also correlated with the expression of TGF-β1.Furthermore, TGF-β1 can induce EMT (P < 0.05).
Conclusion The expression of FoxP3 is correlated with lymph node metastasis and EMT in breast cancer.Therefore, FoxP3 may be a marker for predicting metastasis.

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