周颖, 徐文贵, 戴东, 庹培昱, 刘建井, 黄慧, 左聪. 分化型甲状腺癌肺转移131Ⅰ治疗后全身扫描显像影响因素分析[J]. 中国肿瘤临床, 2013, 40(24): 1558-1562. DOI: 10.3969/j.issn.1000-8179.20131551
引用本文: 周颖, 徐文贵, 戴东, 庹培昱, 刘建井, 黄慧, 左聪. 分化型甲状腺癌肺转移131Ⅰ治疗后全身扫描显像影响因素分析[J]. 中国肿瘤临床, 2013, 40(24): 1558-1562. DOI: 10.3969/j.issn.1000-8179.20131551
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Ying ZHOU, Wengui XU, Dong DAI, Peiyu TUO, Jianjing LIU, Hui HUANG, Cong ZUO. Influencing factor of whole-body scan imaging on radioactive iodine treatment for lung metastases of differentiated thyroid carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(24): 1558-1562. DOI: 10.3969/j.issn.1000-8179.20131551
Citation: Ying ZHOU, Wengui XU, Dong DAI, Peiyu TUO, Jianjing LIU, Hui HUANG, Cong ZUO. Influencing factor of whole-body scan imaging on radioactive iodine treatment for lung metastases of differentiated thyroid carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(24): 1558-1562. DOI: 10.3969/j.issn.1000-8179.20131551
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分化型甲状腺癌肺转移131Ⅰ治疗后全身扫描显像影响因素分析

Influencing factor of whole-body scan imaging on radioactive iodine treatment for lung metastases of differentiated thyroid carcinoma

    摘要
  • 摘要:
      目的  肺部是分化型甲状腺癌（differentiated thyroid carcinoma，DTC）的常见转移部位，131Ⅰ治疗是DTC术后患者肺转移的主要治疗方法，其治疗后常规行131Ⅰ-全身扫描（whole body scan，WBS），本文主要研究DTC肺转移患者WBS显像中肺部病灶显像的影响因素。
      方法  回顾性分析在天津医科大学肿瘤医院分子影像与核素诊疗科行131Ⅰ治疗的DTC肺转移患者60例，治疗前均行甲状腺功能检测、颈胸部CT检查，治疗后行WBS显像。根据WBS肺部转移灶显像情况将患者分为显像阳性组和显像阴性组，分析相关影响因素。
      结果  单因素分析提示，患者的年龄、肺部纤维条索影、钙化影、斑片影等与WBS肺部显像情况相关。双变量Logistic回归分析提示肺部纤维条索影（OR=0.175，P < 0.001）及钙化影（OR=0.088，P < 0.05）不利于WBS肺部转移灶的显像。
      结论  年龄较大患者的WBS肺部病灶显像效果不佳，肺部存在条索影、钙化影、斑片影等不利于WBS肺部转移灶的显像，肺部条索及钙化是影响WBS肺转移灶显像的主要因素。

     

    Abstract:
      Objective  Lung metastases are common in patients with differentiated thyroid carcinoma (DTC). Post-therapeutic 131Ⅰ-whole-body scan (WBS) was conventionally administered after the radioactive iodine treatment (RAI) of DTC lung metastases. This study aimed to investigate the influencing factors of WBS imaging on the RAI of DTC lung metastases.
      Methods  DTC patients (n=60)with lung metastases treated with 131Ⅰ were retrospectively included. Before treatment, the thyroid function was assessed. Neck and chest computed tomography (CT) was performed, and WBS was inspected. Patients with lung metastases were classified into negative andpositive subgroups according to the imaging of 131Ⅰ WBS, and the relative influencing factors were analyzed.
      Results  Univariate analysis showed that age and chest CT imaging, which revealed pulmonary fibrosis, calcification, and patchy shadows, were related to WBS imaging. Binary variable logistic regression analysis revealed that pulmonary fibrosis (OR=0.175, P < 0.001) and calcification (OR= 0.088, P < 0.05) went against the development of WBS.
      Conclusion  WBS imaging on RAI of lung metastases was not obvious in the elderly.The fibrosis, calcification, and patchy shadows of the lung were not conducive for WBS imaging. The fibrosis and calcification of the lung were the main factors that affect WBS imaging.

     

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