Abstract:
Objective This study aims to analyze the therapeutic effect and prognostic factors of carcinoma of parotid gland (CPG).
Methods Data on 103 CPG patients were retrospectively analyzed. The patients were divided into the simple surgery group (Group One) and post-operative radio-chemotherapy group (Group Two). Kaplan-Meier survival analysis, Log-rank test, and Cox regression analysis were employed to analyze the five-year overall survival. Chi-square test was applied to compare the local control rate and recurrence-free survival. Logistic regression analysis was used to determine the correlation between all factors and the local control rate.
Results For all patients, the five-year local control rate, five-year recurrence-free survival rate, and five-year overall survival rate were 71.49%, 69.61%, and 76.10% respectively. The five-year local control ratio (81.96% vs. 61.90%), five-year recurrence-free survival (78.69% vs. 59.52%), and five-year overall survival (88.12% vs. 68.50%) were significantly improved in Group Two compared with Group One. The logistic regression analysis showed that the therapeutic method, T staging, as well as pN(+) neck and tumor differentiation were significantly correlated to the five-year local control rate and five-year recurrence-free survival (P < 0.01). Cox regression analysis showed that therapeutic method, T stage, as well as pN(+) neck and tumor differentiation were significantly correlated to the five-year overall survival (P < 0.01).
Conclusion Post-operative radio-chemotherapy can improve the local control and overall survival rates. This therapeutic method is applicable to patients with T3-4 tumors, as well as pN(+) neck and middle-low differentiation.