Abstract:
Objective To analyze risk factors of cancer patients with Pseudomonas aeruginosa bloodstream infections and drug resistance.
Methods Clinical data of 30 cancer patients with P. aeruginosa bloodstream infection and 90 without infection who were admitted in the Tianjin Medical University Cancer Institute and Hospital between January 2010 and December 2012 were retrospectively analyzed. Whonet 5.6 and SPSS19.0 software were used for statistical analysis of the data.
Results The infection group consisted of 20 male and 10 female patients with a mean age of 60.9±11.2 years. The control group consisted of 60 males and 30 females with a mean age of 51.3 ± 15.9 years. Multivariate logistic regression analysis showed that the number of hospitalization, combined with infection of other sites, and more than two types of antibiotics were independent risk factors of cancer patients with P. aeruginosa bloodstream infections. P. aeruginosa showed high sensitivity(>80%) to carbapenems, ceftazidime, cefepime, aminoglycosides, and fluoroquinolones. The mortality rate of cancer patients with P. aeruginosa bloodstream infections was 60%.
Conclusion Cancer patients with P. aeruginosa bloodstream infections have high mortality. Therefore, comprehensive prevention and control measures must be implemented in clinical practice to reduce P. aeruginosa bloodstream infections.