刘芝华, 张绪森. microRNAs与乳腺癌[J]. 中国肿瘤临床, 2014, 41(2): 87-93. DOI: 10.3969/j.issn.1000-8179.20131944
引用本文: 刘芝华, 张绪森. microRNAs与乳腺癌[J]. 中国肿瘤临床, 2014, 41(2): 87-93. DOI: 10.3969/j.issn.1000-8179.20131944
LIU Zhihua, ZHANG Xusen. MicroRNAs and breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(2): 87-93. DOI: 10.3969/j.issn.1000-8179.20131944
Citation: LIU Zhihua, ZHANG Xusen. MicroRNAs and breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(2): 87-93. DOI: 10.3969/j.issn.1000-8179.20131944

microRNAs与乳腺癌

MicroRNAs and breast cancer

  • 摘要: microRNAs(miRNAs)是一类长约21~24个核苷酸的小分子非编码RNA,通过与位于靶基因mRNA 3' UTR区域的特异性结合位点互补配对结合,促进靶基因mRNA的降解和/或抑制翻译过程,从而行使调节基因表达的功能。miRNAs广泛存在于真核细胞内,参与了细胞的分化、增殖、凋亡、周期调控、迁移以及肿瘤的发生发展等多种生物学进程。miRNAs表达谱是一类潜在的强有力的评估肿瘤发生、发展、诊断、治疗及预后的生物学指标,在人类肿瘤的不同类型中均存在显著差异。乳腺癌是女性最常见的恶性肿瘤之一,不同类型的乳腺癌组织中miRNAs的表达谱也不同。本文对目前为止发现的一些与乳腺癌发生发展、转移及治疗反应等相关的miRNAs及其下游靶基因在乳腺癌中的表达及作用进行综述。

     

    Abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules with 21 to 24 nucleotides in length, which can regulate post-transcriptional gene expression by interacting with the 3' untranslated regions of the target mRNAs. MiRNAs are widely expressed in eukaryotic cells and involved in a variety of biological processes, such as in the development, differentiation, proliferation, and apoptosis of cells. They also play essential roles in cell cycle regulation, migration, and tumor development. MicroRNA expression varies in different human tumors and is considered a powerful potential biological indicator in the development, diagnosis, treatment, and prognosis of cancers. Breast cancer is one of the most common malignancies, and miRNA expression has been found to be differentially expressed in various types of breast cancer. The expression and function of some miRNAs involved in breast cancer development, metastasis, and treatments are briefly summarized in this review.

     

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