Abstract:
Objective The objectives of this study are as follows: 1) to explore the expression level of alpha hydroxybutyric acid dehydrogenase (α-HBDH) in patients with non-Hodgkin's lymphoma (NHL) and its prognostic significance; and 2) to analyze the relationship among α-HBDH, lactate dehydrogenase (LDH), and beta 2-microglobulin (β2-MG), so as to evaluate their diagnostic and prognostic significance.
Methods The expression levels of serum α-HBDH, LDH, and β2-MG were examined in 104 patients with NHL before and after treatment. The relations among the levels of serum LDH, α-HBDH, and β2-MG, as well as their connection with the patients' age, gender, disease stage, and pathological type, were explored.
Results Serum α-HBDH level increased in 35% of the patients and showed a significant correlation with LDH and β2-MG. Significant differences were observed for α-HBDH and β2-MG at different stages but not for LDH. Significant differences were observed between α-HBDH and LDH for different pathological types, but none was found in β2-MG. The three serum enzymes did not exhibit any significant difference for different ages and genders. Levels of serum LDH and α-HBDH showed considerable difference between pre-treatment and post-treatment of patients. Serum β2-MG level did not show any significant change after two or three cycles of chemotherapy.
Conclusion The expression level of serum α-HBDH increases in patients with NHL, is positively correlated with the levels of LDH and β2-MG, and is highly relevant to disease stage and pathological type, regardless of the patients' age and gender. Serum α-HBDH is expected to be a new NHL indicator for tumor load, disease severity, and prognosis.
下载: