付骞千, 纪洪媛, 张甜甜, 高大林, 吴玉, 刘乐, 翟琼莉. 136例中国北方汉族人群经典型霍奇金淋巴瘤与EB病毒感染的相关性研究[J]. 中国肿瘤临床, 2014, 41(10): 629-633. DOI: 10.3969/j.issn.1000-8179.20140394
引用本文: 付骞千, 纪洪媛, 张甜甜, 高大林, 吴玉, 刘乐, 翟琼莉. 136例中国北方汉族人群经典型霍奇金淋巴瘤与EB病毒感染的相关性研究[J]. 中国肿瘤临床, 2014, 41(10): 629-633. DOI: 10.3969/j.issn.1000-8179.20140394
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FU Qianqian, JI Hongyuan, ZHANG Tiantian, GAO1 Dalin, WU Yu, LIU Yue, ZHAI Qiongli. Association between classical Hodgkin's lymphoma and Epstein-Barr virus infection in Northern Chinese Han population[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(10): 629-633. DOI: 10.3969/j.issn.1000-8179.20140394
Citation: FU Qianqian, JI Hongyuan, ZHANG Tiantian, GAO1 Dalin, WU Yu, LIU Yue, ZHAI Qiongli. Association between classical Hodgkin's lymphoma and Epstein-Barr virus infection in Northern Chinese Han population[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(10): 629-633. DOI: 10.3969/j.issn.1000-8179.20140394
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136例中国北方汉族人群经典型霍奇金淋巴瘤与EB病毒感染的相关性研究

Association between classical Hodgkin's lymphoma and Epstein-Barr virus infection in Northern Chinese Han population

    摘要
  • 摘要:
      目的   EB病毒（Epstein-Barr virus，EBV）感染与多种肿瘤的发生关系密切，现已证实EBV感染与经典型霍奇金淋巴瘤（Classical Hodgkin lymphoma，CHL）发生关系尤为密切，但CHL患者中EBV检出率因种族、地域、性别和年龄的不同而有所差异，本研究目的在于探讨中国北方地区CHL发病与EBV感染的相关性。
      方法   用原位杂交的方法检测136例确诊为CHL病例中EBV编码的小RNA（Epstein-Barr virus encoded RNA，EBER）。
      结果   在136例CHL患者中EBER的总阳性率为28%（37/136），其中混合细胞型（mixed cellularity，MC）阳性率最高为49%（23/47）（P < 0.001），其次为富于淋巴细胞型（1ymphocyte rich，LR）30%（3/10），结节硬化型（nodular sclerosis，NS）14%（10/73），淋巴细胞消减型（1ymphocyte depletion，LD）0例（0/2）。CHL发病年龄呈单峰分布，主要在21~30岁年龄组。NS型在21~30年龄组出现一个明显单峰，而MC型在41~50岁年龄组存在一个略低的峰，EBER阳性率在0~10岁和41~50岁这两个年龄组分别有两个峰值（21.6%和24.3%）。
      结论   中国北方汉族人群CHL的发病与EBV的感染有一定的关系，其中以MC与EBV的关系较为密切。

     

    Abstract:
      Objective   The occurrence of numerous tumors, particularly classical Hodgkin's lymphoma (CHL), is related with Epstein-Barr virus (EBV) infection. However, the incidence of CHL and its association with EBV varies significantly with ethnicity, geographic location, sex, and age. This study investigated the association of EBV infection with CHL in Northern Chinese Han population.
      Methods   EBV-encoded small RNA (EBER) was detected in 136 cases of CHL through in situ hybridization.
      Results   A total of 37 cases were EBER positive (28%). The mixed cellularity (MC) subtype had the highest positive EBER rate of 49% (23/47; P < 0.001), followed by lymphocyte-rich subtype with 30% (3/10), nodular sclerosis (NS) subtype with 14% (10/73), and 1ymphocyte depletion with 0% (0/2). Our study identified a single age distribution in the third decade. Moreover, NS subtype showed an evident single peak in the third decade. However, MC subtype had a lower peak in the fifth decade. The incidence of EBER showed a bimodal age distribution with two peaks in the first and fifth decades (21.6% and 24.3%, respectively).
      Conclusions   CHL in Northern Chinese Han population was associated with EBV infection, particularly the MC subtype.

     

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