Abstract: HGK is a germinal center kinase (GCK)-Ⅳ and is involved in controlling cellular processes, such as cell motility, cytoskeleton rearrangement, and cell proliferation. HGK is involved in a very complex network of signaling pathways and interactions involved in diseases, such as diabetes or cancer. HGK was determined to be highly overexpressed in different types of cancers, such as ovarian cancer, hepatocellular carcinoma, lung cancer, pancreatic cancer, and prostate cancer. Recent findings have shown that HGK is a novel target that may provide insight into new therapies to prevent or even treat many metabolic diseases, such as diabetes or even colon cancer, prostate cancer, breast cancer, ovarian cancer, pancreatic cancer, or hepatic cancer.