李超英, 陈文文, 王楚盈, 杨琳琳, 迟源, 张大方. 鸦胆子油口服乳液抑制肝癌发生的实验研究[J]. 中国肿瘤临床, 2014, 41(12): 762-765. DOI: 10.3969/j.issn.1000-8179.20140530
引用本文: 李超英, 陈文文, 王楚盈, 杨琳琳, 迟源, 张大方. 鸦胆子油口服乳液抑制肝癌发生的实验研究[J]. 中国肿瘤临床, 2014, 41(12): 762-765. DOI: 10.3969/j.issn.1000-8179.20140530
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LI Chaoying, CHEN Wenwen, WANG Chuying, YANG Linlin, CHI Yuan, ZHANG Dafang. Inhibition of primary liver cancer by oral javanica oil emulsion[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(12): 762-765. DOI: 10.3969/j.issn.1000-8179.20140530
Citation: LI Chaoying, CHEN Wenwen, WANG Chuying, YANG Linlin, CHI Yuan, ZHANG Dafang. Inhibition of primary liver cancer by oral javanica oil emulsion[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(12): 762-765. DOI: 10.3969/j.issn.1000-8179.20140530
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鸦胆子油口服乳液抑制肝癌发生的实验研究

Inhibition of primary liver cancer by oral javanica oil emulsion

    摘要
  • 摘要:
      目的   探讨鸦胆子油口服乳液对二乙基亚硝胺（DEN）诱导的大鼠原发性肝癌的抑制作用。
      方法   将大鼠随机分为正常对照组、模型对照组、鸦胆子油口服乳液组。采用自由饮水和灌胃给DEN的方法诱发大鼠肝癌模型，诱发肝癌第5周开始灌胃鸦胆子油口服液，5次/周，14周后处死大鼠，腹主动脉取血，全自动生化分析仪检测血清中ALT、AST、ALP、γ-GT和AFP的含量，观察大鼠肝系数、脾系数、胸腺系数、肝脏表面的癌结节数的变化，并进行影像学检查。
      结果   与正常对照组比较，模型对照组肝、脾指数和癌结节数明显增加，胸腺指数明显降低（P < 0.01），血清中ALT、AFP、AST、ALP、γ-GT的水平显著高于正常对照组（P < 0.01）；与模型组比较，鸦胆子油口服乳液显著降低肝癌大鼠肝指数、脾指数、癌结节数，升高胸腺指数（P < 0.01），血清中ALT、AFP、AST、ALP、γ-GT的水平得到明显改善（P < 0.01或P < 0.05）。
      结论   鸦胆子油口服乳液对原发性肝癌具有显著抑制作用，并且作用机制为多方面。

     

    Abstract:
      Objective   This study aimed to investigate the inhibitory effects of Brucea javanica oil oral emulsion (BJOOE) on primary liver cancer induced by diethylnitrosamine (DEN).
      Methods   Rats were randomly divided into the control group, model group, and BJOOE group. Rats were given free access to water. DEN was administered intragastrically to induce liver cancer in rats. Five weeks later, rats were intragastrically administered with BJOOE for five times per week. The rats were killed after 14 weeks. Abdominal aortic blood samples were collected. The contents of ALT, AST, ALP, γ-GT, and AFP of serum were detected by an automatic biochemical analyzer. The liver index, spleen index, thymus index, and changes in liver cancer nodules of the surface were observed in rats. Changes in the number of liver cancer nodules of the surface were detected by imaging.
      Results   Compared with the control group, the liver index, spleen index, and number of nodules of the model group significantly increased, whereas the thymus index significantly decreased (P < 0.01). The levels of ALT, AFP, AST, ALP, and γ-GT of serum in the model group were significantly higher than those in the control group (P < 0.01). Compared with the model group, BJOOE significantly reduced the liver index, spleen index, and number of cancer nodules, but increased the thymus index in the liver of rats with cancer (P < 0.01). The levels of ALT, AFP, AST, ALP, and γ-GT of serum in rats with hepatic carcinoma significantly improved (P < 0.01 or P < 0.05).
      Conclusion   BJOOE couldinhibit primary liver cancer, and the underlying mechanisms are complex.

     

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