Abstract:
Objective This study aims to investigate the correlation and significance between the expression of P53 and epithelial-mesenchymal transition (EMT) in breast cancer.
Methods The expression patterns of P53, Twist, Snail, E-cadherin, N-cadherin, Vimentin, and Fibronectin protein were detected via immunohistochemistry in 63 cases with breast carcinoma. The correlation of P53 protein with clinicopathologic features and survival of breast carcinoma, as well as the relationship between the expression of P53 and EMT, was analyzed.
Results The expression rates of P53, Twist, Snail, and EMT are 44.4% (28/63), 54.0% (34/63), 68.3% (43/63), and 41.3% (26/63), respectively. The P53 protein expression is correlated with tumor grade (P < 0.05) but not with other clinicopathologic features (P>0.05). The expression of P53 is also correlated with the expression of Twist and Snail, which are associated with EMT(P < 0.05). Multivariate survival analysis reveals that lymph node metastasis, P53, and EMT are independent prognostic factors.
Conclusion The expression of P53 is correlated with tumor grade and EMT in breast cancer, which can be used as an independent prognostic factor. Therefore, P53 may be an effective target for breast cancer therapy.