Abstract:
Objective To detect the expression of the human papilloma virus (HPV) 16 and HPV18 in esophageal squamous cell carcinoma in Minnan area.
Methods Real-time fluorescence quantitative polymerase chain reaction (FQ-PCR) was applied to detect HPV DNA in 100 esophageal carcinoma sample and 100 normal tissues beside the tumor.
Results The positive rates of high-risk HPV 16 and HPV 18 infection in Minnan esophageal carcinoma and in normal tissues beside the tumor were 14.00%, 15.00% and 7.00%, 8.00%, respectively. The positive rates of lymph node and non-lymph node metastases were 40.98% and 10.25%, respectively. These results exhibited statistical significance (P < 0.01). HPV 16 and HPV 18 infection was uncorrelated with patient age, pathological type, and tumor grade (P>0.05).
Conclusion HPV16 and HPV 18 infection was correlated to esophageal squamous cell carcinoma in Minnan areas. Such infection may also contribute to the occurrence and development of esophageal squamous cell carcinoma.