吴培仁, 尤俊, 洪清琦. 闽南地区人乳头状瘤病毒16及18感染与食管鳞癌的关系[J]. 中国肿瘤临床, 2014, 41(15): 968-970. DOI: 10.3969/j.issn.1000-8179.20140695
引用本文: 吴培仁, 尤俊, 洪清琦. 闽南地区人乳头状瘤病毒16及18感染与食管鳞癌的关系[J]. 中国肿瘤临床, 2014, 41(15): 968-970. DOI: 10.3969/j.issn.1000-8179.20140695
shu
WU Peiren, YOU Jun, HONG Qingqi. Relationship of HPV 16 and HPV 18 with esophageal squamous cell carcinoma in Minnan area[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(15): 968-970. DOI: 10.3969/j.issn.1000-8179.20140695
Citation: WU Peiren, YOU Jun, HONG Qingqi. Relationship of HPV 16 and HPV 18 with esophageal squamous cell carcinoma in Minnan area[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(15): 968-970. DOI: 10.3969/j.issn.1000-8179.20140695
shu

闽南地区人乳头状瘤病毒16及18感染与食管鳞癌的关系

Relationship of HPV 16 and HPV 18 with esophageal squamous cell carcinoma in Minnan area

    摘要
  • 摘要:
      目的   探讨人乳头状瘤病毒16、18型（HPV16、18）感染与闽南食管鳞癌发生的关系。
      方法   采用实时荧光定量聚合酶链反应（FQ-PCR）技术对出生生长于闽南人100例食管鳞癌组织和相应癌旁组织进行HPV-DNA检测。
      结果   高危型HPV16、18在食管鳞癌组织和相应癌旁组织中的阳性率分别为14.00%、15.00%和7.00%、8.00%；淋巴结转移组与无转移组的HPV16、18感染率分别为40.98%和10.25%，差异具有统计学意义（P < 0.01）；与患者年龄、病理类型、肿瘤分级均无相关性，均P>0.05。
      结论   HPV16、18感染与闽南地区食管鳞癌存在相关性，可能是闽南地区食管鳞癌发生的重要因素之一。

     

    Abstract:
      Objective   To detect the expression of the human papilloma virus (HPV) 16 and HPV18 in esophageal squamous cell carcinoma in Minnan area.
      Methods   Real-time fluorescence quantitative polymerase chain reaction (FQ-PCR) was applied to detect HPV DNA in 100 esophageal carcinoma sample and 100 normal tissues beside the tumor.
      Results   The positive rates of high-risk HPV 16 and HPV 18 infection in Minnan esophageal carcinoma and in normal tissues beside the tumor were 14.00%, 15.00% and 7.00%, 8.00%, respectively. The positive rates of lymph node and non-lymph node metastases were 40.98% and 10.25%, respectively. These results exhibited statistical significance (P < 0.01). HPV 16 and HPV 18 infection was uncorrelated with patient age, pathological type, and tumor grade (P>0.05).
      Conclusion   HPV16 and HPV 18 infection was correlated to esophageal squamous cell carcinoma in Minnan areas. Such infection may also contribute to the occurrence and development of esophageal squamous cell carcinoma.

     

    • HTML全文
    • 参考文献(18)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回