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摘要: 原发性精囊腺癌是一种极其罕见的恶性肿瘤，目前尚无统一的诊治标准，应与前列腺癌、直肠癌、膀胱癌等相鉴别。完整切除肿瘤是较公认的治疗方法之一，因早期缺乏特异性临床表现且极其罕见，故发现时多为晚期，预后较差。2012年7月华中科技大学同济医学院附属同济医院收治1例精囊腺癌患者，年龄51岁，患者行局部切除术，术后有肉眼肿瘤残留，术后病理为原发性精囊腺癌。术后采用紫杉醇(175 mg/m2)联合顺铂(60 mg/m2) 6个疗程的化疗方案，静脉滴注，盆腔局部行60 Gy/30次适形放疗，取得一定疗效，目前患者定期随访。Abstract: Primary seminal vesicle adenocarcinoma (PSVA) is an extremely rare disease without any unified diagnostic criterion. Differential diagnosis of PSVA from prostate cancer, colon cancer, and bladder cancer is necessary but difficult because of the lack of standard management. Radical resection is considered the mainstay of primary treatment that offers satisfactory prognosis. Most cases with PSVA are diagnosed at advanced stages because its early manifestation is nonspecific and it is rarely diagnosed in clinic. In this study, we described the case of a 52 year-old PSVA patient who was treated at the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, in July 2012. The patient underwent local excision, with tumor residuals visible under the naked eye. The patient benefits from a six-cycle paclitaxel (175 mg/m2) therapeutic regimen combined with cisplatin (60 mg/m2), as well as pelvic modulated radiotherapy with a radiation dose of 60 Gy/30 F. At present, the patient is disease-free and undergoes regular follow-up.
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Key words:
- seminal vesicle adeno-carcinoma /
- diagnosis /
- treatment
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图 1 精囊腺癌患者病理切片(HE)
Figure 1. Pathology of seminal vesicle adeno-carcinoma
A:H&E×40; B: H&E×100
图 2 患者术后盆腔MRI检查
Figure 2. Pelvic MRI of the patient after surgery
A. Sagittal plane; B. Transverse plane
表 1 精囊腺癌及其周围组织肿瘤的相关标志物对照
Table 1. Comparison of related markers among seminal vesicle adenocar⁃ cinoma and tumors of neighboring tissues
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