CPP-ACP预防头颈部肿瘤患者放射性龋齿和牙本质敏感的临床研究

张德辉; 张小涛; 彭洪; 孙海涛

doi:10.3969/j.issn.1000-8179.20141018

CPP-ACP预防头颈部肿瘤患者放射性龋齿和牙本质敏感的临床研究

doi: 10.3969/j.issn.1000-8179.20141018

张德辉^①,,
张小涛^②, ,,
彭洪^③,
孙海涛^①

①.
首都医科大学附属北京世纪坛医院口腔科（北京市 100038）
②.
青岛大学医学院第二附属医院，青岛市肿瘤医院肿瘤防治中心
③.
首都医科大学附属北京世纪坛医院耳鼻喉科

详细信息

作者简介:
张德辉专业方向为牙体牙髓病牙周病治疗。E-mail：qdzlyy2014@126.com

通讯作者:
张小涛 zljyjd@126.com

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出版历程
- 收稿日期: 2014-06-24
- 修回日期: 2014-08-11
- 刊出日期: 2020-12-29

Casein phosphopeptide-amorphous calcium phosphate nanocomplexes as a preventive agent for radiation caries and dental sensitivity in irradiated head and neck cancer patients

ZHANG Dehui^{①
,},
ZHANG Xiaotao^{②
, ,},
PENG Hong^③,
SUN Haitao^①

①.
Department of Stomatology, Beijing Shijitan Hospital Affiliated to Capital University of Medical Sciences, Beijing 100038, China
②.
Cancer Prevention and Treatment Center, Qingdao Cancer Hospital and The Second Affiliated Hospital of Qingdao University, Qingdao 266042, China
③.
Department of Otorhinolaryngology, Beijing Shijitan Hospital Affiliated to Capital University of Medical Sciences, Beijing 100038, China

More Information

Corresponding author: Xiaotao ZHANG; E-mail: zljyjd@126.com

摘要

摘要: 目的比较酪蛋白磷酸多肽-无定形磷酸钙（CPP-ACP）的再矿化糊剂和Duraphat Varnish保护漆预防头颈部肿瘤患者放射性龋齿和牙本质敏感的疗效。方法 112例头颈部肿瘤患者，随机分为CPP-ACP再矿化糊剂组（实验组）和Duraphat Varnish保护漆组（对照组）。实验组：含900 ppm的CPP-ACP再矿化糊剂于放疗前1天起涂抹牙面，1次/天，疗程为5周；对照组：含5%氟化钠的Duraphat Varnish保护漆于放疗前1天起涂抹牙面，1次/天，疗程为5周。分别观察两组患者放疗前、放疗后12个月的龋失补牙数（DMFT）、龋失补牙面数（DMFS）和牙本质敏感程度并进行比较。结果两组放疗前，DMFT、DMFS和牙本质敏感程度差异无统计学意义（P>0.05）。与放疗前比较，放疗后12个月两组DMFT、DMFS和牙本质敏感程度均明显升高，且对照组的DMFT、DMFS和牙本质敏感程度较实验组升高更明显（P < 0.05）。结论 CPP-ACP在预防头颈部肿瘤患者放射性龋齿和牙本质敏感方面有较好疗效，值得临床应用。
- 酪蛋白磷酸多肽-无定形磷酸钙 /
- 放射性龋齿 /
- 龋失补牙数 /
- 龋失补牙面数 /
- 牙本质敏感
Abstract: Objective To compare the efficacy of casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) and Duraphat varnish on preventing radiation caries and dentin hypersensitivity (DH) in irradiated head and neck cancer patients. Methods A total of 112 patients with head and neck cancer who will undergo radiotherapy were selected and randomly divided into the CPP-ACP group (experimental group) and the Duraphat varnish group (control group). A day prior to the scheduled radiotherapy, CPP-ACP containing paste had been applied once a day for 5 weeks to the teeth surface of the experimental group. Duraphat varnish was applied with the same frequency in the control group. The decay missing filling tooth (DMFT), decay missing filling surface (DMFS), and DH of two groups before radiotherapy and 12 months after radiotherapy were observed and statistically analyzed. Results Before radiotherapy, DMFT, DMFS, and DH showed no significant differences between the groups (P>0.05). However, significant increase in DMFT, DMFS, and DH was noted in the two groups 12 months after the radiotherapy (P < 0.05). A higher increase was observed in the DMFT, DMFS, and DH of the control group compared with those in the experimental group (P < 0.05). Conclusion CPP-ACP effectively reduced radiation caries and sensitivity in irradiated head and neck cancer patients and deservesclinical application.
- CPP-ACP /
- radiation caries /
- decay missing filling tooth /
- decay missing filling surface /
- dentin hypersensitivity

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表 1 放疗前和放疗后12个月两组患者DMFT和DMFS比较（x±s）

Table 1. Comparison of the DMFT and DMFS numbers between the experimental group and control group before radiotherapy and 12 months after radiotherapy(x±s)

表 2 放疗前和放疗后l2个月两组患者牙本质敏感度比较（x±s）

Table 2. Comparison of the dental sensitivity between the experimental and control group before radiotherapy and 12 months after radiotherapy(x±s)

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