李慧兰, 李帅, 翟丽丽, 付丽. PARP1及其活性产物PAR在三阴性乳腺癌中的表达及意义[J]. 中国肿瘤临床, 2014, 41(24): 1564-1567. DOI: 10.3969/j.issn.1000-8179.20141138
引用本文: 李慧兰, 李帅, 翟丽丽, 付丽. PARP1及其活性产物PAR在三阴性乳腺癌中的表达及意义[J]. 中国肿瘤临床, 2014, 41(24): 1564-1567. DOI: 10.3969/j.issn.1000-8179.20141138
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LI Huilan, LI Shuai, ZHAI Lili, FU Li. Expression and significance of PARP1 and PAR in triple-negative breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(24): 1564-1567. DOI: 10.3969/j.issn.1000-8179.20141138
Citation: LI Huilan, LI Shuai, ZHAI Lili, FU Li. Expression and significance of PARP1 and PAR in triple-negative breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(24): 1564-1567. DOI: 10.3969/j.issn.1000-8179.20141138
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PARP1及其活性产物PAR在三阴性乳腺癌中的表达及意义

Expression and significance of PARP1 and PAR in triple-negative breast cancer

    摘要
  • 摘要:
      目的  探讨聚腺苷酸二磷酸核糖转移酶（poly ADP-ribose polymerase，PARP）1及其活性产物聚腺苷酸二磷酸核糖（poly ADP-ribose，PAR）在三阴性乳腺癌（triple negative breast cancer，TNBC）及非TNBC中的表达及其意义。
      方法  应用免疫组织化学染色方法检测PARP1及PAR在107例TNBC及116例非TNBC中表达差异，将患者分为TNBC组和非TNBC组。
      结果  PARP1与PAR均在细胞质或（和）细胞核呈现着色表达，TNBC组细胞核PARP1表达（χ2=9.258，P=0.002）及细胞质PARP1表达（χ2=3.879，P=0.049）均高于非TNBC组；TNBC组细胞核PAR表达低于非TNBC组（χ2=6.163，P=0.013），而细胞质PAR阳性表达明显高于非TNBC组（χ2=7.454，P=0.006）。比较细胞核/细胞质PARP1及PAR表达，均未发现PARP1与PAR表达存在明显的相关性。
      结论  在TNBC组细胞核/细胞质中PARP1均高表达，并较易表现为细胞质PAR阳性表达及细胞核PAR低表达，且PARP1与PAR表达无明显相关性。

     

    Abstract:
      Objective  To investigate the expression and significance of poly adenosine diphosphate (ADP)-ribose polymerase (PARP1) and its active product poly ADP-ribose (PAR) in triple-negative breast cancer (TNBC) and non-TNBC.
      Methods  Immunohis-tochemical staining was used to detect different expression patterns of PARP1 and PAR in 107 TNBC and 116 non-TNBC cases.
      Results:  Immunohistochemical staining revealed different cytoplasmic and nuclear PARP1 and PAR expression patterns. Nuclear PARP1 (χ2=9.258; P=0.002) and cytoplasmic PARP1 (χ2= 3.879; P=0.049) expression was higher in the TNBC group than in the non-TNBC group. The nuclear PAR expression was lower in the TNBC group than in the non-TNBC group (χ2=6.163; P=0.013). By contrast, the PAR cytoplasmic expression was significantly higher in the TNBC group than in the non-TNBC group (χ2=7.454; P=0.006). No signifi-cant correlation existed between the PAR and PARP1 expression patterns either in the cytoplasm or in the nucleus.
      Conclusion  Nuclear or cytoplasmic PARP1 was highly expressed in TNBC. High cytoplasmic and low nuclear PAR expression patterns were commonly ob-served in TNBC. No significant correlation existed between PARP1 and PAR expression.

     

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