税莲, 何敏, 刘映江, 龚春梅, 张炼. 高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性[J]. 中国肿瘤临床, 2014, 41(23): 1517-1520. DOI: 10.3969/j.issn.1000-8179.20141176
引用本文: 税莲, 何敏, 刘映江, 龚春梅, 张炼. 高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性[J]. 中国肿瘤临床, 2014, 41(23): 1517-1520. DOI: 10.3969/j.issn.1000-8179.20141176
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SHUI Lian, HE Min, LIU Yingjiang, GONG Chunmei, ZHANG Lian. Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(23): 1517-1520. DOI: 10.3969/j.issn.1000-8179.20141176
Citation: SHUI Lian, HE Min, LIU Yingjiang, GONG Chunmei, ZHANG Lian. Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(23): 1517-1520. DOI: 10.3969/j.issn.1000-8179.20141176
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高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性

Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta

    摘要
  • 摘要:
      目的  观察高强度聚焦超声消融兔腹主动脉旁肝肿瘤后肝肿瘤剂量学、磁共振图像、病理学及生存期影响, 评价HIFU消融兔腹主动脉旁肝肿瘤安全性和有效性。
      方法  分别于HIFU组(32只)和对照组(20只)实验兔建立腹主动脉旁的VX2肝肿瘤模型, HIFU组瘤兔于MR引导的高强度聚焦超声消融肿瘤, 分析腹主动脉旁肿瘤消融剂量学, MR观察消融前后肿瘤影像学变化, 病理学观察肿瘤消融后坏死情况, 对比观察HIFU组与对照组瘤兔生存期。
      结果  MRI和病理学均表明MR引导下HIFU能完全消融兔腹主动脉旁VX2肝肿瘤, EEF为25.72±11.40 J/mm3 HIFU组的生存期明显高于对照组, 差异具有统计学意义(P < 0.05)。
      结论  HIFU能安全有效消融兔腹主动脉旁VX2肝肿瘤并且能明显提高存活期。

     

    Abstract:
      Objective  To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation for the VX2 liver tumor near the hepatic main blood vessels of rabbits by using dosimetry and magnetic resonance imaging (MRI) and by analyzing pathological changes and survival.
      Methods  Rabbits with VX2 liver tumor adjacent to the abdominal aorta were divided into the HIFU (n=32) and control groups (n=20).MRI-guided HIFU was employed for the ablation of the liver tumor in the HIFU group.The ablation volume and the energy efficiency factor (EEF) of the 32 ablated rabbits were further analyzed.MRI and pathology were used to compare the changes in the tumor before and after HIFU.The survival of the animals in the HIFU and control groups was also determined.
      Results  Both pathology and imaging showed that the rabbit liver VX2 tumor adjacent to the abdominal aorta was completely ablated, with an EEF of (25.72±11.40) J/mm3.The survival rate was significantly higher in the HIFU group than in the control group (P < 0.05).
      Conclusion  HIFU ablation is safe and effective in rabbit VX2 liver tumor near the abdominal aorta.This approach significantly increases survival.

     

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