miR-17-92基因簇在骨肉瘤中的表达及其临床意义
Expression of miR-17-92 cluster in osteosarcoma and its clinical significance
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摘要:目的 探讨人骨肉瘤组织和邻近正常骨组织中miR-17-92基因簇的表达情况及其临床意义。方法 运用Q-PCR法检测63例骨肉瘤组织及邻近部位正常骨组织中miR-17-92基因簇的表达水平, 并分析miR-17-92基因簇表达与患者临床病理特征及预后的关系。结果 miR-17-92在所有组织中均有表达, 且在肿瘤组织中表达明显高于在正常组织中的表达(P < 0.05), 另外, miR-17-92基因簇高表达患者预后更差, 差异有统计学意义(P=0.027)。结论 miR-17-92基因簇在骨肉瘤组织和邻近正常骨组织中表达存在差异性, 可能在骨肉瘤发生、发展过程中起重要作用, 有望成为骨肉瘤患者预后一种新的指标。Abstract:Objective To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its association with clinical significance.Methods Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues.Normal bone tissues from 63 patients were matched, and the relationships between the expression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored.Results The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P < 0.05).The high expression of miR-17-92 had a significant correlation with reduced survival (P=0.027).Conclusion The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis.
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