赵兵, 李迅, 刘炜, 李妍, 赵振慧, 杨顺娥. 新疆维汉弥漫大B细胞淋巴瘤中Bcl-6 c-myc基因易位的差异性研究[J]. 中国肿瘤临床, 2014, 41(19): 1244-1248. DOI: 10.3969/j.issn.1000-8179.20141310
引用本文: 赵兵, 李迅, 刘炜, 李妍, 赵振慧, 杨顺娥. 新疆维汉弥漫大B细胞淋巴瘤中Bcl-6 c-myc基因易位的差异性研究[J]. 中国肿瘤临床, 2014, 41(19): 1244-1248. DOI: 10.3969/j.issn.1000-8179.20141310
shu
ZHAO Bing, LI Xun, LIU Wei, LI Yan, ZHAO Zhenhui, YANG Shun'e. Difference of Bcl-6 and c-myc gene translocation between Xinjiang Uygur and Han diffused large B-cell lymphoma subtypes[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(19): 1244-1248. DOI: 10.3969/j.issn.1000-8179.20141310
Citation: ZHAO Bing, LI Xun, LIU Wei, LI Yan, ZHAO Zhenhui, YANG Shun'e. Difference of Bcl-6 and c-myc gene translocation between Xinjiang Uygur and Han diffused large B-cell lymphoma subtypes[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2014, 41(19): 1244-1248. DOI: 10.3969/j.issn.1000-8179.20141310
shu

新疆维汉弥漫大B细胞淋巴瘤中Bcl-6 c-myc基因易位的差异性研究

Difference of Bcl-6 and c-myc gene translocation between Xinjiang Uygur and Han diffused large B-cell lymphoma subtypes

    摘要
  • 摘要:
      目的  探讨新疆维吾尔族、汉族弥漫大B细胞淋巴瘤（diffuse large B-cell lymphoma，DLBCL）患者Bcl-6、c-myc基因易位的差异及其临床意义。
      方法  采用荧光免疫原位杂交（FISH）方法，对233例DLBCL活体石蜡切片进行Bcl-6、c-myc基因检测。观察Bcl-6、c-myc基因易位与DLBCL患者临床资料的关系，并对不同民族在不同亚型DLBCL中Bcl-6、c-myc基因易位的情况进行比较。
      结果  233例DLBCL中，Bcl-6基因重排51例，占21.89%；c-myc基因重排39例，占16.74%；Bcl-6基因易位的表达与患者年龄、性别、发病部位、临床分期和LDH水平无显著相关（P＞0.05），而与民族、IPI评分、结外侵犯、B症状、DLBCL不同亚型和近期疗效有相关性（P < 0.05）；c-myc基因易位的表达与患者年龄、性别、发病部位、临床分期、LDH水平和DLBCL不同亚型无明显相关性（P＞0.05），而与民族、IPI评分、结外侵犯、B症状和近期疗效有相关性（P < 0.05）；维、汉不同民族GCB中Bcl-6、c-myc基因易位比较差异均无统计学意义（P＞0.05）；维、汉不同民族非生发中心活化B细胞（non-GCB）中Bcl-6、c-myc基因易位比较差异有统计学意义（P < 0.05）。
      结论  Bcl-6，C-myc基因易位的表达与维、汉不同民族、IPI评分、结外侵犯、B症状和近期疗效有相关性；维、汉民族non-GCB亚组中Bcl-6、c-myc基因易位存在差异。

     

    Abstract:
      Objective   To investigate the clinical significance of Bcl-6, c-myc gene abnormalities in Xinjiang Uygur and Han diffused large B-cell lymphoma (DLBCL) subtypes.
      Methods   Bcl-6, c-myc gene was detected by fluorescence in situ hybridization in 233 patients with DLBCL. A relationship was observed among Bcl-6, c-myc gene translocation, and clinical data in DLBCL patients. In addition, a difference was observed among Bcl-6, c-myc gene translocation, and different ethnic groups in different subtypes of DLBCL.
      Results   Among the 233 patients, 51 cases (21.89%) had rearranged Bcl 6 gene, and 39 cases (16.74%) had rearranged c-myc gene. Bcl-6 gene translocation and expression was related with age, gender, disease location, clinical stage, and LDH levels (P＞0.05), but was not related with nationality, international prognostic index score, extranodal involvement, B symptoms, DLBCL subtypes, and recent efficacy (P < 0.05); c-myc gene translocation and expression was related with age, gender, disease location, clinical stage LDH levels, and DLBCL subtypes (P＞0.05), but was not related with nationality, IPI score, extranodal involvement, B symptoms, and recent efficacy (P < 0.05). In the Uygur and Han GCB groups, Bcl-6, c-myc gene translocation showed no significant difference (P＞0.05). By contrast, in the Uygur and Han non-GCB groups, Bcl-6, c-myc gene translocation showed significant difference (P＞0.05).
      Conclusion   Bcl-6, C-myc gene translocation was related with age, gender, disease location, clinical stage, and LDH levels. Bcl-6 gene translocation was also correlated with different subtypes of DLBCL.

     

    • HTML全文
    • 参考文献(15)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回