Abstract:
Objective To investigate the clinical significance of Bcl-6, c-myc gene abnormalities in Xinjiang Uygur and Han diffused large B-cell lymphoma (DLBCL) subtypes.
Methods Bcl-6, c-myc gene was detected by fluorescence in situ hybridization in 233 patients with DLBCL. A relationship was observed among Bcl-6, c-myc gene translocation, and clinical data in DLBCL patients. In addition, a difference was observed among Bcl-6, c-myc gene translocation, and different ethnic groups in different subtypes of DLBCL.
Results Among the 233 patients, 51 cases (21.89%) had rearranged Bcl 6 gene, and 39 cases (16.74%) had rearranged c-myc gene. Bcl-6 gene translocation and expression was related with age, gender, disease location, clinical stage, and LDH levels (P>0.05), but was not related with nationality, international prognostic index score, extranodal involvement, B symptoms, DLBCL subtypes, and recent efficacy (P < 0.05); c-myc gene translocation and expression was related with age, gender, disease location, clinical stage LDH levels, and DLBCL subtypes (P>0.05), but was not related with nationality, IPI score, extranodal involvement, B symptoms, and recent efficacy (P < 0.05). In the Uygur and Han GCB groups, Bcl-6, c-myc gene translocation showed no significant difference (P>0.05). By contrast, in the Uygur and Han non-GCB groups, Bcl-6, c-myc gene translocation showed significant difference (P>0.05).
Conclusion Bcl-6, C-myc gene translocation was related with age, gender, disease location, clinical stage, and LDH levels. Bcl-6 gene translocation was also correlated with different subtypes of DLBCL.