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摘要: 恶性肿瘤患者营养不良发生率较高, 严重营养不良增加了患者的死亡率, 降低了抗癌治疗的效果, 增加了治疗相关的不良反应发生率, 延长住院时间, 降低了患者的生存质量。因此, 营养支持已成为恶性肿瘤多学科综合治疗的重要组成部分。合理、有效地提供营养支持对大部分肿瘤患者具有积极意义, 这已成为共识。Abstract: Patients with malignant tumors usually suffer from malnutrition. This condition increases morbidity and mortality, decreases the efficacy of anticancer treatments, increases the risk of therapy-associated side effects, increases the length of hospital stay, and degrades the quality of life of patients. These effects of malnutrition highlight the need for adaptive nutritional support for each step of a multimodal cancer treatment.
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Key words:
- neoplasm /
- cancer cachexia /
- nutritional support
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[1] Batista ML Jr, Peres SB, McDonald ME, et al. Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors[J]. Cytokine. 2012; 57(1):9-16. doi: 10.1016/j.cyto.2011.10.008 [2] Donohoe CL, Ryan AM, Reynolds JV. Cancer cachexia: mechanisms and clinical implications[J]. Gastroenterol Res Pract. 2011: 601434. http://cn.bing.com/academic/profile?id=d64eefa9892b731aaf2de9fa1bd2c107&encoded=0&v=paper_preview&mkt=zh-cn [3] Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus[J]. Lancet Oncol. 2011; 12(5):489-495. doi: 10.1016/S1470-2045(10)70218-7 [4] Tisdale MJ. Mechanisms of cancer cachexia[J]. Physiol Rev. 2009; 89(2):381-410. doi: 10.1152/physrev.00016.2008 [5] Gullett NP, Mazurak VC, Hebbar G, et al. Nutritional interventions for cancer-induced cachexia[J]. Curr Probl Cancer. 2011; 35 (2):58-90. doi: 10.1016/j.currproblcancer.2011.01.001 [6] Santarpia L, Contaldo F, Pasanisi F. Nutritional screening and early treatment of malnutrition in cancer patients[J]. J Cachexia Sarcopenia Muscle. 2011; 2(1):27-35. doi: 10.1007/s13539-011-0022-x [7] Bozzetti F. Nutritional support of the oncology patient[J]. Crit Rev Oncol Hematol. 2013; 87(2):172-200. doi: 10.1016/j.critrevonc.2013.03.006 [8] Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation [J]. Science. 2009, 324(5930):1029-33. doi: 10.1126/science.1160809 [9] White JP. Muscle oxidative capacity during IL-6-dependent cancer cachexia[J]. Am J Physiol Regul Integr Comp Physiol. 2011, 300(2):201-211. doi: 10.1152/ajpregu.00300.2010 [10] Lis CG. Role of nutritional status in predicting quality of life outcomes in cancer-a systematic review of the epidemiological literature[J]. Nutr J. 2012, 11:27. doi: 10.1186/1475-2891-11-27 [11] Johns N, Stephens NA, Preston T. Muscle protein kinetics in cancer cachexia[J]. Curr Opin Support Palliat Care. 2012; 6(4):417-423. doi: 10.1097/SPC.0b013e328359e6dd [12] Lee SJ, Glass DJ.Treating cancer cachexia to treat cancer[J]. Skelet Muscle. 2011, 1(1):2. doi: 10.1186/2044-5040-1-2 [13] Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling[J]. J Clin Invest. 2011; 121 (9):3375-3383. doi: 10.1172/JCI57158 [14] Mauri D. Cancer cachexia: global awareness and guideline implementation on the web[J]. BMJ Support Palliat Care. 2013; 3(2):155-160. http://cn.bing.com/academic/profile?id=4e7dbfae85c2afcb22e9a6301dd73954&encoded=0&v=paper_preview&mkt=zh-cn [15] Bozzetti F. ESPEN Guidelines on Parenteral Nutrition: non-surgical oncology. Clin Nutr. 2009, 28(4): 445-454.
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