Abstract: Objective: To investigate clinical and hematological features of malignant lymphoma (ML) combined with venous thromboembolism (VTE). Methods:The clinical data of 65 patients with ML combined with VTE were collected between October 2010 and April 2014 and then retrospectively reviewed. Coagulation function and hemorheology were analyzed. Results:The proportion of males and females among patients with ML combined with VTE was 2.61 :1. ML combined with VTE was mainly observed in patients with end-stage cancer. The highest incidence ( 81.54%) of ML combined with VTE was found in StageⅢB-Ⅳtumor. Among 65patients with VTE, 43 (66 .15 %) were found after ML was diagnosed, 55 (84 .62 %) were deep vein thrombosis (DVT),7 (10 .77 %) were pulmonary embolism (PE), and 3 (4.62 %) were complicated with both DVT and PE. Common DVT locations were the upper limb and the neck vein of 37 cases ( 67 .27 %). Clinical manifestations of ML combined with DVT are limb pain, swelling, and increased skin temperature. Unexplained difficulty in breathing, chest pain, and syncope are also found in ML combined with PE. The total effective rate of55 cases with DVT was49 .09 %, and the rate of those cases with PE was 14 .29 %. The levels of platelet aggregation, D-dimer, high cut blood viscosity, low cut blood viscosity, plasma viscosity, hematocrit, assembly index of erythrocyte, and rigidity index of erythrocyte were significantly higher in patients with ML combined with VTE than in patients with ML alone; by contrast, APTT, erythrocyte sedimentation rate, deformability index of erythrocyte, and average velocity of blood flow were reduced in patients with ML combined with VTE than in patients with ML alone. Conclusion: DVT, which exhibits high incidence in males, is the most common type observed in ML combined with VTE. DVT is commonly manifested in the upper limb and the neck vein; furthermore, DVT is mainly observed in patients with end-stage cancer. Hematological indexes indicated changes in the sensitivity state of thromboembolism.