Abstract: The adenocarcinoma of the esophagogastric junction (EGJA) is located in a unique anatomical position and at the junction of the squamous epithelium and the columnar epithelium. The biological characteristics of this disease are different from those of esophageal or gastric cancer. The diagnostic classification of EGJA has been subject to controversies, and no gold standard therapeu-tic regimens have been established, especially in the choice of treatment of locally advanced EGJA. Results from large-scale clinical tri -als and imaging technology development showed that the treatment of EGJA has been individualized. Furthermore, this problem high -lights the importance of multidisciplinary collaboration. This article focuses on current progress in studies on EGJA.