王丹丹①②, 陈 情①, 毕 平②. 肺癌左全肺切除术后心肺并发症的发生与术前低肺功能的相关性[J]. 中国肿瘤临床, 2015, 42(7): 397-400. DOI: 10.3969/j.issn.1000-8179.20141952
引用本文: 王丹丹①②, 陈 情①, 毕 平②. 肺癌左全肺切除术后心肺并发症的发生与术前低肺功能的相关性[J]. 中国肿瘤临床, 2015, 42(7): 397-400. DOI: 10.3969/j.issn.1000-8179.20141952
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Dandan WANG, Qing CHEN, Ping BI. Correlation analysis of preoperative reduced pulmonary function and postoperative cardiopulmonary complication after left pneumonectomy for lung cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(7): 397-400. DOI: 10.3969/j.issn.1000-8179.20141952
Citation: Dandan WANG, Qing CHEN, Ping BI. Correlation analysis of preoperative reduced pulmonary function and postoperative cardiopulmonary complication after left pneumonectomy for lung cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(7): 397-400. DOI: 10.3969/j.issn.1000-8179.20141952
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肺癌左全肺切除术后心肺并发症的发生与术前低肺功能的相关性

Correlation analysis of preoperative reduced pulmonary function and postoperative cardiopulmonary complication after left pneumonectomy for lung cancer

    摘要
  • 摘要: 目的：探讨肺癌患者术前轻度低肺功能对左全肺切除术后心肺并发症（postoperative cardiopulmonary complication，PCC ）的预测能力，以期作为指导临床手术参考。方法：回顾性分析我院200 例施行左全肺切除手术的肺癌患者的临床资料，根据患者术后1 个月内有无发生心肺并发症分为PCC 组和无PCC 组，探讨术前轻度或中重度低肺功能与患者术后并发症发生的相关性，并进一步探讨肺通气功能指标（FEV 1% 、MVV% ）轻度减低与术后PCC 的关系。结果：200 例患者中正常、轻度及中重度肺功能减低各35、45、120 例，术后1 个月内PCC 发生率分别为28.6% ，53.3% ，62.5% ，差异具有统计学意义（χ2= 12.611，P = 0.002）；术前FEV 1% 轻度减低（70% ≤ FEV 1< 80%）或MVV% 轻度减低（70% ≤ MVV%<80%）与左全切术后PCC 的发生相关（P = 0.028 及0.014）。进一步分析显示，FEV 1% 或MVV% 单独轻度减低时，患者术后PCC 的发生差异无统计学意义（P > 0.05），而FEV 1 和MVV同时轻度减低时，PCC 的发生差异有统计学意义（χ2= 6.598，P = 0.010）。 结论：术前FEV 1% 或MVV% 轻度减低是影响肺癌左全肺切除后PCC的危险因素。FEV 1% 或MVV% 单独轻度减低不能影响肺癌左全肺切除后PCC 的发生，同时满足FEV 1% 及MVV% 轻度减低是肺癌左全切术后PCC 发生的危险因素，应加强围手术期管理，降低PCC 的发生。

     

    Abstract: Objective:To investigate the value of preoperative slight decline of the pulmonary function in predicting postoperative cardiopulmonary complications (PCC) after left total pneumonectomy of lung cancer patients to guide the clinical surgery of lung can -cer. Methods:Clinical data of 200 lung cancer patients after left total pneumonectomy were retrospectively analyzed. These patients were divided into two groups (PCC and non- PCC) based on the incidence of postoperative cardiopulmonary complications within 1 month after the cancer resection. The relationship between the preoperative slight or moderate to severe reduction of pulmonary func-tion and postoperative complications was explored. The correlation between the preoperative slight decline of the pulmonary function index and PCC was also analyzed. Results:Among the 200 patients, 35, 45, and 120 demonstrated normal, slightly, and moderately to severely reduced pulmonary functions, and 28.6% ,53.3% , and62.5% showed PCC within1 month after the surgical resection (χ2=12.611, P=0.002). Significant differences in the slightly reduced pulmonary function parameters MVV% ( 70% ≤ MVV< 80% ) and FEV 1% (70% ≤ FEV 1% < 80%) were observed between those without and with complications (P=0.028 and 0.014). Further analysis indicated no significant difference between the patients with preoperative slight reduction of FEV 1% only or of MVV% only (P>0.05). However, statistically significant differences were observed when both FEV1% and MVV% were slightly reduced (χ2=6.598, P=0.010). Conclusion:The preoperative slight reduction values of FEV1% and MVV% were the risk factors in predicting PCC after left pneumo-nectomy in lung cancer patients. The slightly reduced FEV1% or MVV% alone cannot influence PCC. Both slightly reduced FEV1% and MVV% were the risk factors of PCC. Perioperative management should be strengthened for these patients to lower the incidence of PCC.

     

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