Abstract: Objective: To analyze the pathologic types and clinical characteristics of lymphoma in Shandong, China. Methods: The clinical data of lymphoma patients admitted from September2011 to September 2014in Shandong Cancer Hospital and the Affiliat-ed Hospital of Shandong Academy of Medical Sciences were retrospectively analyzed. Data included age, sex, pathologic classification, and onset locus of lymphoma.Results:The clinical data of 520 lymphoma cases were collected. The ratio of male to female was 1.2:1, and the median age was51years old. Among these patients, 67cases ( 12.9% ) were Hodgkin's lymphoma (HL), whereas 453 cases (87.1% ) were non- Hodgkin's lymphoma (NHL). Among NHL cases,75.9% were B- cell NHL and24.1% were T/ natural killer- cell NHL. Nodular sclerosis classical Hodgkin's lymphoma was the most common pathologic type of HL, comprising 52.2%. The age of HL onset did not present twin peaks. In NHL, 245 cases ( 54.1% of NHL) were diffuse large B-cell lymphoma (DLBCL). The constituent ra-tio of DLBCL was higher than in other countries and regions ( 18% to 42.7%), in which the ratio of male to female was0.9:1, and the age of onset was slightly earlier (median age was 54years old). Lymph nodes in the cervical region were the most commonly involved in the disease, and NHL extranodal onset was frequently observed. Conclusion:Among the 520 cases of lymphoma, DLBCL is the most common subtype. Most subtypes show male predominance, but female predominance was observed for DLBCL. The commonly involved sites of extranodal lymphoma are the nasal cavity and gastrointestinal tract.