Abstract: Objective: To investigate differences in the clinical curative effects of percutaneous biliary metal stents and stents combined with 125I particles for intracavitary irradiation treatment of malignant jaundice in cholangiocarcinoma. Methods:A total of 52 patients with malignant obstructive jaundice caused by cholangiocarcinoma that was unsuitable for radical curative surgery were select-ed. All of the patients were subjected to simple stenting and subsequently divided into two groups: the control group ( 26cases) and the treatment group (26cases). The treatment group consisted of patients who received implantation of 125I particles. Routine biochemistry tests were performed, and maximum and minimum tumor diameters were measured and assessed before and after treatment to detect statistically significant differences. The jaundice and survival time of patients between the two groups were also noted and compared. Results:The liver function of patients in both groups improved significantly at1, 3, and 6 months compared with that before operation; differences observed were statistically significant ( P<0.05). No significant difference in postoperative bilirubin levels was observed be-tween patients in the two groups (P>0.05). Significant differences in bilirubin levels were observed between groups as follows: liver functions of patients are different in preoperative 3 and 6 months after treatment and preoperative; postoperative3 months and 1 month after treatment; and postoperative 6 months and 3 months after treatment in two groups,differences observed were statistically significant (P<0.05). Tumor size significantly decreased in the treatment group after therapy but significantly increased in the control group; differences observed were statistically significant ( P<0.05). Patients in the treatment group showed an average survival time of 12.83±1.57months and 24-month survival rate of 38.46%. In the control group, the average survival time was8.89± 1.0 months and the24-month survival rate was 11 .54% . Again, differences observed were statistically significant (P<0.05). Conclusion:Similar to simple stent implantation, intracavitary irradiation with percutaneous biliary metal stents combined with 125I particles reduced jaundice. The use of stents with 125I particles effectively inhibited tumor growth, increased the stent latency time, and prolonged patient survival. Further -more, the inside source type is conducive to recycling more conveniently to observe the curative effect and adjust the particle position, additional therapeutic dose, and radioactive materials.