Abstract: Colorectal cancer is one of the most common malignancies with a high risk of liver metastasis in China. Compared with systemic chemotherapy, hepatic arterial infusion (HAI) transports cytotoxic agents directly into the hepatic artery, leading to the persistent level of medicine in tumor cells and the relative lower systemic concentration. With advances in HAI, this technique has been successfully used not only as the pre- and post-operative chemotherapy for the resection of colorectal liver metastases, but also as an ad -juvant chemotherapy after the colorectal radical surgery to prevent the liver metastasis. This review discusses the application and per -spective of HAI in the treatment of colorectal cancer liver metastasis.