Abstract: FOXM 1 is a member of the FOX family of transcription factors and has been confirmed to participate in cell prolifera-tion and cell cycle progress. FOXM 1 has been reported to play an important role in more than 20types of human neoplasms, and its up-regulation promotes tumor cell proliferation, invasion, metastasis, chemotherapy drug resistance, and resistance to apoptosis. In recent years, various studies have shown that FOXM 1 also plays an important role in tumor metabolism. The metabolism of cancer cells deter-mines the growth and survival of cancer, and metabolic alteration is a key feature of tumor cells. The connection between metabolic ab-normalities and tumorigenesis has been reported. The O-linked β -N-acetylglucosamine transferase regulates the expression of FOXM 1, which helps tumor cells survive without damage caused by oxidative stress. This review aims to summarize the known relationships of FOXM 1 and tumor cell metabolism, as well as its role in the potential pathways of tumor metabolism.