Abstract: Objective:To investigate the expression of vasculogenic mimicry (VM) in endometrial carcinoma tissues and its rela -tionship with the clinicopathologic features and prognosis of the disease. Methods:A total of 267 paraffin-embedded endometrial carci -noma specimens of patients with complete follow-up data were collected from the Shijiazhuang Bethune International Peace Hospital between January 2005and June 2014. CD 31-PAS dual staining was performed to identify the VM structure. Tissue samples were then divided into VM-positive and VM-negative groups. CD 133 expression was detected by immunohistochemical streptavidin peroxidase method.Results:Among the 267 endometrial carcinoma patients, 65cases ( 24.3%) were VM positive. VM formation was closely corre-lated with the International Federation of Gynecology and Obstetrics Staging ( χ2=9.987, P=0.002), histodifferentiation grade (χ2=11 .795, P=0.001), myometrial invasion depth (χ2=5.499, P=0.019), vascular cancer embolus (χ2=22.599, P<0.001), and lymph node me -tastasis ( χ2=7.848, P=0.005). Kaplan-Meier survival curve analysis showed that survival time was significantly shorter in the VM-posi -tive group (median survival time was 51months) than in the VM-negative group (median survival time was 100 months) ( χ2=70.973, P<0.001). Moreover, CD 133 expression was significantly higher in the VM-positive group 75.4% (49/65) than in the VM-negative group 58.9% (119/202) (χ2=5.720, P=0.017). Conclusion:VM is closely correlated with the pathogenesis, development, and malignancy of endometrial carcinoma. Furthermore, VM is one of the important indexes influencing the prognosis of this disease. Therefore, CD 133-positive cells may contribute to VM formation.