Abstract: Objective:To assess the survival-predictive value of TNM and Lugano staging systems in patients with primary gastro-intestinal lymphoma (PGL). Methods:A total of 73patients with PGL were recruited from February 2001to August 2013. All patients were diagnosed according to the TNM and Lugano staging systems. Five-year survival rate was used as the major clinical outcome. Sur-vival curves were plotted using the Kaplan–Meier method and analyzed with the log-rank test. The prognostic value of different vari-ables for clinical outcomes was assessed using the Cox multiple regression model.Results:The median follow-up time of surviving pa-tients was 42.4 months (range:1.3- 158.6 months). The estimated 5- year overall survival rate was 77.82% . When diagnosed with the TNM system, the 5-year survival rates in stages Ⅰ, Ⅱ, Ⅲ, and Ⅳwere 100%,90.0%,67.4%, and 22.2%, respectively (χ2=17.7956, P=0.0005). When staged by the Lugano system, the 5- year survival rates in stages Ⅰ, Ⅱ, ⅡE , and Ⅳwere 100% ,100% ,70.7% , and 46.2% , respectively (χ2=15.6776, P=0.0013). Cox analysis showed that the invasion depth (T) (P=0.0181) and metastasis (M) ( P=0.0031) were covariates that were prognostically significant for the overall survival. Conclusion:The TNM staging system is more ac -curate than the Lugano system in predicting the5-year survival rate of patients with PGL.