Abstract: Objective: To investigate the effect of different analgesia methods on blood coagulation in patients who underwent esophageal carcinoma surgery through thrombelastography (TEG). Methods:A total of 60patients who underwent radical esophagecto -my were randomly divided into the patient- controlled epidural analgesia (PCEA) group and patient- controlled intravenous analgesia (PCIA) group with 30cases each. The visual analogue scale (VAS) and patient-controlled analgesia (PCA) bottom pressing times were recorded at 6, 12, 24, and 48h after surgery. The TEG parameters were measured at the time before anesthesia (T0), the end of surgery (T 1), first day after operation (T 2), second day after operation (T 3), and third day after operation (T 4). Results: (1) Compared with the PCIA group, the VAS scores and PCA bottom pressing times were significantly lower ( P<0.05). (2) The R and K values of the PCEA group had no significant difference compared with T 0 (P>0.05), and were significantly prolonged than those in the PCIA group at T 2, T3, and T 4 (P<0.05). (3) The platelet amount of the two groups decreased at T 2 and T3 compared with that at T 0 (P<0.05). Conclu-sion:The analgesic effect of PCEA was better than that of PCIA in patients who underwent esophageal carcinoma surgery, and may im-prove their hypercoagulability.