Abstract: Objective:To approach the clinicopathologic characteristics, treatment modalities, and prognosis of the patients with double primary carcinoma of endometrial carcinoma and colorectal carcinoma and analyze the relationship between this disease and Lynch syndrome. Methods:The clinicopathologic and follow-up data of 34cases with double primary carcinoma of endometrial carci -noma and colorectal carcinoma treated in Cancer Hospital of Chinese Academy of Medical Sciences were reviewed. Results:The medi -an age of the34patients was 51.5 years old (ranging from 39to 76). Twenty-two of the total cases (22/34, 64.7%) had tumor family his-tory. The pathologic results indicated that 79.4% (27/34) was endometrioid adenocarcinoma. In the 34cases, 33were treated by surgical procedure. Of the33cases undergoing surgery, 17patients with endometrial carcinoma and 19with colorectal carcinoma received fur-ther adjuvant treatment of chemotherapy、 and /or radiotherapy. The 2- and 5-year survival rates were84.3% and 63.1% in the34cases, respectively.Conclusion:The age of onset is earlier in the patients with double primary carcinoma than in those with sporadic colorec -tal carcinoma. Some cases have cancer family history, and their survival rates are similar to those of the patients with sporadic colorec -tum carcinoma. Diagnosis of some patients with double primary carcinoma may be in line with Lynch syndrome.