Abstract: Oxycodone sustained-release tablet is a new formulation of potent opioids, which are characterized by their exact anal -gesic effect, high safety for oral administration, and slight adverse drug reaction. Oxycodone improves the quality of life of patients with cancer pains and is among the selected drugs used for controlling moderate and severe cancer pains. Relief from prolonged pain is achieved by adjusting the dose of Oxycontin (oxycodone hydrochloride) sustained release tablet according to its pharmacological char -acteristics. The details are reviewed in this article.