Abstract: Objective:To investigate the correlations of Lauren classification and world health organization (WHO) classification of gastric cancer (GC) with microvascular density (MVD), matrix metalloproteinase- 2 (MMP- 2), matrix metalloproteinase- 9 (MMP- 9), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor1 (VEGFR 1), vascular endothelial growth factor receptor 2 (VEGFR 2), and p53 . Methods:The clinical data of 89 patients with GC were collected. The collected specimens were categorized on the basis of Lauren classification and WHO classification. CD34 /periodic acid-Schiff (PAS) double staining was performed to validate MVD. Immunohistochemistry was conducted to investigate the expression levels of MMP- 2, MMP-9, VEGF, VEGFR 1, VEGFR 2, and p 53 . Results: MVD was not correlated with Lauren classification or WHO classification (P>0.05 ). Lauren typing was associated with the expression levels of MMP- 9, VEGFR 1, and p 53 (P<0.05 ). WHO classification was not related to any of the factors (P>0.05 ). Cox proportional hazards model revealed that Lauren classification and WHO classification were the prognostic factors of overall survival (P<0.05 ). Conclusion: This research on tumor related factors, angiogenesis, and different classifications of GC may provide new methods to treat this disease.