韩懿①, 劳美琼①, 雷巧如②, 李艳娜①. 宫颈癌中长链非编码RNA CRNDE 表达及其临床意义[J]. 中国肿瘤临床, 2015, 42(14): 705-708. DOI: 10.3969/j.issn.1000-8179.20150535
引用本文: 韩懿①, 劳美琼①, 雷巧如②, 李艳娜①. 宫颈癌中长链非编码RNA CRNDE 表达及其临床意义[J]. 中国肿瘤临床, 2015, 42(14): 705-708. DOI: 10.3969/j.issn.1000-8179.20150535
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Yi HAN1, Meiqiong LAO1, Qiaoru LEI2, Yanna LI1. Expression and clinical significance of long non-coding RNA CRNDE in cervical cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(14): 705-708. DOI: 10.3969/j.issn.1000-8179.20150535
Citation: Yi HAN1, Meiqiong LAO1, Qiaoru LEI2, Yanna LI1. Expression and clinical significance of long non-coding RNA CRNDE in cervical cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(14): 705-708. DOI: 10.3969/j.issn.1000-8179.20150535
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宫颈癌中长链非编码RNA CRNDE 表达及其临床意义

Expression and clinical significance of long non-coding RNA CRNDE in cervical cancer

    摘要
  • 摘要: 目的：探讨长链非编码RNA（LncRNA）CRNDE在宫颈癌中表达及其临床意义。方法：收集广东省开平市中心医院行手术切除的宫颈癌组织及癌旁组织标本87例，实时荧光定量PCR（RT-PCR）检测LncRNACRNDE 表达差异，分析其与临床病理特征的关系。结果：与癌旁组织比较 LncRNACRNDE 在宫颈癌组织中呈高表达（P < 0.05）。LncRNACRNDE 高表达与宫颈癌 FI GO分期，淋巴结转移，肿瘤的侵袭深度相关。此外，LncRNACRNDE 高表达较低表达者的生存时间缩短（P < 0.05）。 Cox 回归多因素分析发现LncRNACRNDE 可作为宫颈癌患者独立的预后因子。结论：LncRNACRNDE 可作为宫颈癌独立的预后标志物和潜在的治疗靶点。

     

    Abstract: Objective:To investigate the expression and clinical significance of long non-coding RNA (LncRNA) CRNDE in cer -vical cancer.Methods:Specimens of cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 87pa -tients who underwent surgery in the Kaiping Central Hospital, China. Quantitative real-time PCR was used to examine the expression of LncRNA CRNDE, and its correlation with clinicopathological features was analyzed. Results:LncRNA CRNDE expression was sig-nificantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues ( P<0.05). Increased LncRNA CRNDE expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion (P<0.05). Moreover, a higher ex -pression of LncRNA CRNDE demonstrated significantly poorer overall survival in cervical cancer patients than in those with lower Ln-cRNA CRNDE expression ( P<0.05). Multivariate analyses suggested that LncRNA CRNDE expression served as an independent pre-dictor for overall survival. Conclusion:Our findings posit that LncRNA CRNDE may be a potential prognostic marker and therapeutic target for cervical cancer.

     

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