刘奔①, 张熙凝①②, 陈可欣①. 组蛋白赖氨酸甲基转移酶SET8 对蛋白的甲基化修饰及与肿瘤相关性的研究进展*[J]. 中国肿瘤临床, 2015, 42(15): 765-769. DOI: 10.3969/j.issn.1000-8179.20150553
引用本文: 刘奔①, 张熙凝①②, 陈可欣①. 组蛋白赖氨酸甲基转移酶SET8 对蛋白的甲基化修饰及与肿瘤相关性的研究进展*[J]. 中国肿瘤临床, 2015, 42(15): 765-769. DOI: 10.3969/j.issn.1000-8179.20150553
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Ben LIU1, Xining ZHANG1, 2. Research progress on histone lysine methyltransferase SET8 in methylation modification and association with tumor[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(15): 765-769. DOI: 10.3969/j.issn.1000-8179.20150553
Citation: Ben LIU1, Xining ZHANG1, 2. Research progress on histone lysine methyltransferase SET8 in methylation modification and association with tumor[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(15): 765-769. DOI: 10.3969/j.issn.1000-8179.20150553
shu

组蛋白赖氨酸甲基转移酶SET8 对蛋白的甲基化修饰及与肿瘤相关性的研究进展*

Research progress on histone lysine methyltransferase SET8 in methylation modification and association with tumor

    摘要
  • 摘要: 组蛋白赖氨酸甲基转移酶SET 8 属于SET 基因家族成员，是目前发现的唯一可以特异性催化H 4 赖氨酸20单甲基化（H 4K 20me1）的赖氨酸甲基转移酶（KMTs）；此外，SET 8 还可甲基化p53、TWIST 、Wnt及ERα 等非组蛋白，并通过调节转录过程影响相应基因的表达，进而参与调控细胞周期、染色质固缩和DNA 的复制。有研究提示，SET 8 的单核苷酸多态性与多种肿瘤的发生发展有潜在的相关性。本文就SET 8 对组蛋白和非组蛋白的修饰、microRNA对SET 8 的调节及SET 8 与肿瘤相关性的研究进展进行了综述，旨在为揭示肿瘤的发病机制和筛选治疗靶点提供帮助。

     

    Abstract: SET 8 is a member of SET gene family. SET 8 is the only histone methyltransferase (KMT) that can uniquely catalyze histone monomethylation of H 4 lysine 20(H4K20me1). Furthermore, SET 8 can methylate other non- histone proteins, such as p 53, TWIST, Wnt, and ER α . SET 8 can affect the expression of the corresponding genes through gene transcription regulation. SET 8 subse-quently contributes to the regulation of gene transcription, cell cycle, chromatin condensation, and DNA replication. Population studies suggested that a single nucleotide polymorphism on SET 8 gene is potentially associated with the development of various tumors. In this review, we focus on research progress on SET 8 function in histone and non-histone modifications, microRNA regulatory role on SET 8, and SET 8's correlation with tumor. We aim to reveal cancer pathogenesis and contribute to the screening of therapeutic targets.

     

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