Abstract: Objective: To evaluate the feasibility of hypofractionated intensity- modulated radiation therapy (IMRT) combined with concurrent chemotherapy in patients with locally advanced squamous cell carcinoma of the hypopharynx. Methods:Patients with stageⅢ- ⅣA carcinoma of the hypopharynx were treated with IMRT and cisplatin-based concurrent chemotherapy. Two groups were di -vided according to the prescription dose to the primary gross tumor volume, as follows: Cohort- 1 comprised patients who were recruit -ed before February 2013(70Gy/33F and2.12Gy/F); and Cohort- 2 comprised patients who were recruited since February 2013(69Gy/30F and 2.30Gy/F). Acute toxicities were evaluated. This study was registered with the number ChiCTR-ONRC- 14004240. Results: Between August 2008and December 2014, a total of 76patients ( 35in Cohort-1 and 41in Cohort-2) were recruited. No xerostomia of grade3 and higher was observed in all patients, who showed low incidences of grade3 skin reaction, oral mucositis, and dysphagia. All patients did not show acute toxicities of higher than grade 4. No statistical differences in acute toxicities were observed between the two cohorts. No statistical difference was observed in acute toxicities between the IMRT techniques. Induction chemotherapy was the inde -pendent prognostic factor for grade 2 xerostomia (P=0.002). Conclusion:The 69Gy/30F hypofractionated IMRT was safe and effec-tive in the treatment of locally advanced squamous cell carcinoma of the hypopharynx. Late toxicities and long-term outcome need to be investigated further.