Abstract: Objective:To explore the clinicopathological factors in node-negative colon cancer patients with synchronous liver metasta -ses and to improve the efficiency of follow- up and rate of early diagnosis for high- risk patients. Methods:Clinical data of140 colon cancer patients who underwent operation from January2008to December 2012in Beijing Cancer Hospital were analyzed. The high-risk variables associated with synchronous liver metastases were subjected to univariate and multivariate analyses. Results: Synchro-nous liver metastases developed in 13out of the140 node-negative colon cancer patients. Eight out of those 13patients ( 61. 5%) ex-hibited complications with incomplete colon obstruction, and6 cases underwent surgical treatment for both primary tumor and liver metastases. Both univariate and multivariate analyses revealed that preoperative abnormal serum carcinoembryonic antigen levels (≥ 5 ng/mL) and vascular invasion were significant independent risk factors for synchronous liver metastases. Conclusion: The risk of syn -chronous liver metastases for colon cancer patients with negative lymph node is slightly high. Vascular invasion and abnormal preoper -ative CEA levels are significant independent risk factors for synchronous liver metastases. Specific examination of livers is necessary for the special cohort at the time of diagnosis or after operation to avoid misdiagnosis.